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Synaptic Plasticity in the Cerebellar Cortex and its Role in Motor Learning

Published online by Cambridge University Press:  18 September 2015

Ito Masao
Ito Masao*
Affiliation:
Frontier Research Program, Saitama, Japan
*
Frontier Research Program, Riken, Wako, Saitama 351-01, Japan
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Abstract:

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Synaptic plasticity plays a role in the learning capability of brain tissues. Long-term depression (LTD) of parallel fiber synapses in cerebellar Purkinje cells occurs when these synapses are activated in conjunction with climbing fiber synapses. Signal transduction mechanisms underlying LTD have recently been investigated extensively. It has also become apparent that climbing fiber signals encode errors in the motor performance of an animal. It is therefore hypothesized that learning proceeds in cerebellar tissues in such a way that error signals of climbing fibers act to depress by LTD those parallel fiber synapses responsible for the errors. The cerebellum contains a large number of corticonuclear microcomplexes. Each microcomplex is connected to an extracerebellar system and is presumed to endow the system with learning capability. The hypothesis accounts for the adaptation of the vestibuloocular reflex and probably also for other forms of motor and cognitive learning.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S70 - S74
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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