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Substance P-like Immunoreactivity and Analgesic Effects of Vibratory Stimulation on Patients Suffering From Chronic Pain

Published online by Cambridge University Press:  18 September 2015

Régis Guieu ,
Marie-Françoise Tardy-Gervet  and
Pierre Giraud
Régis Guieu*
Affiliation:
Laboratoire de Biochimie, UER de Medecine, secteur Nord, URA CNRS 1455, Marseilles, France (R.G.); Laboratoire de Neurobiologie Humaine, Université de Provence, URA CNRS 372, Marseilles, France (M.-F.T.-G.); UER de Medecine, secteur Nord. INSERM U297. Marseilles. France (P.G.)
Marie-Françoise Tardy-Gervet
Affiliation:
Laboratoire de Biochimie, UER de Medecine, secteur Nord, URA CNRS 1455, Marseilles, France (R.G.); Laboratoire de Neurobiologie Humaine, Université de Provence, URA CNRS 372, Marseilles, France (M.-F.T.-G.); UER de Medecine, secteur Nord. INSERM U297. Marseilles. France (P.G.)
Pierre Giraud
Affiliation:
Laboratoire de Biochimie, UER de Medecine, secteur Nord, URA CNRS 1455, Marseilles, France (R.G.); Laboratoire de Neurobiologie Humaine, Université de Provence, URA CNRS 372, Marseilles, France (M.-F.T.-G.); UER de Medecine, secteur Nord. INSERM U297. Marseilles. France (P.G.)
*
Laboratoire de Neurobiologie Humaine, Universite de Provence, URA CNRS 372, Avenue Escadrilire Normandie Nienien 13397 Marseilles Cedex 13 (France)
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Abstract:

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By applying vibratory stimulation to patients suffering from pain, it is possible to set up an inhibitory control on the pain pathways which is based on the activation of large-sized afferent fibres. The exact mechanisms responsible for these analgesic effects still remain to be determined, however. For this purpose, we investigated in the present study whether or not the analgesic effects were accompanied by a decrease in the CSF substance P-like immunoreactivity levels (SPLI) of seven patients suffering from chronic pain, who were fitted with a ventriculo-peri-toneal drain. The SPLI levels were determined before and after 30-min vibratory stimulation sessions. The results show that the SPLI levels decreased as the result of the vibration, but this decrease seems to be too slight to account for the pain relief obtained.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 2 , May 1993 , pp. 138 - 141
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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