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Structural and Molecular Compartmentation in the Cerebellum

Published online by Cambridge University Press:  18 September 2015

Hawkes Richard ,
Blyth Steven ,
Chockkan Vijay ,
Tano David ,
Ji Zhongqi  and
Mascher Christa
Hawkes Richard*
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
Blyth Steven
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
Chockkan Vijay
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
Tano David
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
Ji Zhongqi
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
Mascher Christa
Affiliation:
Department of Anatomy and Neuroscience Research Group, University of Calgary, Calgary
*
Department of Anatomy, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1
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Abstract:

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Most descriptions treat the cerebellum as a uniform structure, and the possibility of important regional heterogeneities in either chemistry or physiology is rarely considered. However, it is now clear that such an assumption is inappropriate. Instead, there is substantial evidence that the cerebellum is composed of hundreds of distinct modules, each with a precise pattern of inputs and outputs, and expressing a range of molecular signatures. By screening a monoclonal antibody library against cerebellar polypeptides we have identified antigens – zebrins – that reveal some of the cerebellum’s covert heterogeneity. This article reviews some of these findings, relates them to the patterns of afferent connectivity, and considers some possible mechanisms through which the modular organization may arise.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S29 - S35
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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