Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-28T13:12:11.015Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum Lipoprotein Fatty Acid Profile in Hereditary Ataxias

Published online by Cambridge University Press:  18 September 2015

L. Iorio ,
G. De Michele ,
A. Filla ,
L. Di Martino ,
A. Postiglione ,
L. Patti  and
G. Campanella
L. Iorio*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
G. De Michele*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
A. Filla*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
L. Di Martino*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
A. Postiglione*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
L. Patti*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
G. Campanella*
Affiliation:
Departments of Neurology (G.D.M., A.F., L.D.M., G.C.), and Internal Medicine (A.P., L.R), Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (L.I.), Pozzilli, Italy
*
Clinica Neurologica. Seconda Facoltà di Medicina, via Pansini 5, 80131 Napoli, Italy
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We investigated the serum fatty acid profiles of cholesterol esters, phospholipids and triglycerides in 24 patients with Friedreich's disease and 16 patients with other forms of spinocerebellar degeneration. In 8 patients with Friedreich's disease we also analyzed the fatty acid profile of the lipoprotein fractions. We found no major differences in fatty acid profiles between ataxic patients and sex and age-matched controls; in particular there was no decrease of linoleic acid in Friedreich's disease. The level of linoleic acid in serum cholesterol esters decreased with increasing disability of patients.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 3 , August 1993 , pp. 206 - 209
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Harding, AE. Classification of the hereditary ataxias and spastic paraplegias. Lancet 1983; i: 1151–1155.CrossRefGoogle Scholar
2.Filla, A, De, Michele G, Caruso, G, Marconi, R, Campanella, G. Genetic data and natural history of Friedreich's disease: a study of 80 Italian patients. J Neurol 1990; 237: 345–351.CrossRefGoogle ScholarPubMed
3.Chamberlain, S, Shaw, J, Rowland, A, et al.Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature 1988; 334: 248–249.CrossRefGoogle ScholarPubMed
4.Rosenberg, RN. Autosomal dominant cerebellar phenotypes: the genotype will settle the issue. Neurology 1990; 40: 1329–1331.CrossRefGoogle ScholarPubMed
5.Barbeau, A. The Quebec Cooperative Study of Friedreich's Ataxia: 1974-1984; 10 years of research. Can J Neurol Sei 1984; 11: 646–660.CrossRefGoogle Scholar
6.Yao, JK, Ellefson, RD, Dyck, PJ. Lipid abnonnalities in hereditary neuropathy. Part I. Serum non polar lipids. J Neurol Sei 1976; 29: 161–175.CrossRefGoogle Scholar
7.Davignon, J, Huang, YS, Wolf, JB, Barbeau, A. Fatty acid profile of major lipid classes in plasma lipoproteins of patients with Freidreich's ataxia: demonstration of a low linoleic acid content most evident in the cholesterolester fraction. Can J Neurol Sei 1979; 6: 275–283.CrossRefGoogle Scholar
8.Walker, JL, Chamberlain, S, Robinson, N. Lipids and lipoproteins in Friedreich's ataxia. J Neurol Neurosurg Psychiatry 1980; 43: 111–117.CrossRefGoogle ScholarPubMed
9.Baker, RWR, Thompson, RHS, Zilkha, KJ. Serum fatty acid in multiple sclerosis. J Neurol Neurosurg Psychiatry 1964; 27: 408–414.CrossRefGoogle ScholarPubMed
10.Kunze, D, Reichman, G, Egger, E, Leuschner, G, Eckhardt, H. Erythrozytenlipide bei progressiver Muskeldystrophie. Clin Chim Acta 1973; 43: 333–341.CrossRefGoogle Scholar
11.Campanella, G, Filla, A, De, Falco FA, Mansi, D, Durivage, A. et al.Friedreich's ataxia in the south of Italy: a clinical and biochemical survey of 23 patients. Can J Neurol Sei 1980; 7: 351–358.CrossRefGoogle ScholarPubMed
12.Canter, GJ, De, la Torre R, Mier, M. A method for evaluating disability in patients with Parkinson's disease. J Nerv Ment Dis 1961; 133: 143–147.CrossRefGoogle ScholarPubMed
13.Folch, J, Lees, M, Sloane-Stanley, GH. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem 1957; 226: 497–509.CrossRefGoogle Scholar
14.Skipski, VP, Peterson, RF, Barclay, M. Separation of phosphatidyl ethanolamine, phosphatidyl serine, and other phospholipids by thin-layer chromatography. J Lipid Res 1962; 3: 467–470.CrossRefGoogle Scholar
15.Morrison, WR, Smith, LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids in the boron fluoride-niethanol. J Lipid Res 1964; 5:600–608.CrossRefGoogle Scholar
16.Hatch, FT, Lees, RS. Practical method for plasma lipoprotein analysis. Adv Lipid Res 1968; 6: 1–68.CrossRefGoogle ScholarPubMed