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Sensorimotor Perineuritis – An Autoimmune Disease?

Published online by Cambridge University Press:  18 September 2015

Christopher N. Bourque ,
Brian A. Anderson ,
C. Martin del Campo  and
Anders A. F. Sima
Christopher N. Bourque
Affiliation:
Department of Medicine, Section of Neurology, St. Boniface General Hospital and the Department of Pathology
Brian A. Anderson*
Affiliation:
Department of Medicine, Section of Neurology, St. Boniface General Hospital and the Department of Pathology
C. Martin del Campo
Affiliation:
Department of Medicine, Section of Neurology, St. Boniface General Hospital and the Department of Pathology
Anders A. F. Sima
Affiliation:
Department of Medicine, Section of Neurology, St. Boniface General Hospital and the Department of Pathology
*
Section of Neurology, St. Boniface General Hospital. 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
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Abstract:

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The literature contains a single description of sensory perineuritis (Asbury et al 1972). These patients demonstrated a painful, distal, sensory neuropathy, and examination of peripheral nerve biopsies revealed focal thickening and inflammatory infiltrates of the perineurium. We report a patient with sensorimotor peripheral nerve dysfunction, accompanied by progressive slowing of nerve conduction velocity. Examination of a sural nerve biopsy demonstrated focal thickening of the perineurium, inflammatory infiltrates, and necrosis of perineurial cells. Immunohistology revealed a patchy precipitation of IgG and IgM on perineurial cells. Ultrastructurally, mononuclear cells were found adjacent to perineurial cells undergoing necrosis. The patient showed gradual improvement partially coinciding with a course of steroid therapy. We suggest that this neuropathy is caused by damage to the perineurial barrier possibly by an immune-mediated destruction of perineurial cells and subsequent compression of the endoneurial content by perineurial scarring.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 2 , May 1985 , pp. 129 - 133
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

1.Asbury, AK., Picard, EH., Baringer, JR.Sensory perineuritis Arch Neurol 1982; 16: 302–312Google Scholar
2.Konishi, T., Saida, K., Ohnishi, A., et al. Perineuritis in monoeuritis multiplex with cyroglobulinemia. Muscle Nerve 1982; 5: 173–177CrossRefGoogle Scholar
3.Thomas, PK., Olsson, Y.Microscopic anatomy and function of the connective tissue components of peripheral nerve. In: Dyck, PJ., Thomas, PK., and Lambert, EH., eds. Peripheral neuropathy. Philadelphia: WB Saunders Co, 1975: 168–189Google Scholar
4.Spencer, PS., Weinberg, HJ., Raine, CS., et al. The Perineurial window — A new model of focal demyelination and remyelination. Brain Res 1975;96: 323–329CrossRefGoogle Scholar
5.Pencek, TL., Schauf, CL., Low, PA., etal. Disruption of the perineurium in amphibian peripheral nerve: morphology and physiology. Neurology 1980; 30: 593–399CrossRefGoogle ScholarPubMed
6.Nesbitt, JA., Ackland, RD.Histopathological changes following removal of the perineurium. J Neurosurg 1980; 53: 233–238CrossRefGoogle ScholarPubMed
7.Sunderland, S.Nerves and Nerve Injuries. Second edition Edinburgh, London, and New York: Churchill Livingstone, 1978: 64–65Google Scholar