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Role of the Ipsilateral Motor Cortex in Voluntary Movement

Published online by Cambridge University Press:  18 September 2015

Robert Chen ,
Leonardo G. Cohen  and
Mark Hallett
Robert Chen*
Affiliation:
Human Cortical Physiology Unit, Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
Leonardo G. Cohen
Affiliation:
Human Cortical Physiology Unit, Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
Mark Hallett
Affiliation:
Human Cortical Physiology Unit, Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
*
Building 10, Room 5N226, 10 Center Drive MSC-1428, NINDS, NIH, Bethesda, MD 20892-1428 USA
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Abstract:

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The ipsilateral primary motor cortex (M1) plays a role in voluntary movement. In our studies, we used repetitive transcranial magnetic stimulation (rTMS) to study the effects of transient disruption of the ipsilateral M1 on the performance of finger sequences in right-handed normal subjects. Stimulation of the M1 ipsilateral to the movement induced timing errors in both simple and complex sequences performed with either hand, but with complex sequences, the effects were more pronounced with the left-sided stimulation. Recent studies in both animals and humans have confirmed the traditional view that ipsilateral projections from M1 to the upper limb are mainly directed to truncal and proximal muscles, with little evidence for direct connections to distal muscles. The ipsilateral motor pathway appears to be an important mechanism for functional recovery after focal brain injury during infancy, but its role in functional recovery for older children and adults has not yet been clearly demonstrated. There is increasing evidence from studies using different methodologies such as rTMS, functional imaging and movement-related cortical potentials, that M1 is involved in ipsilateral hand movements, with greater involvement in more complex tasks and the left hemisphere playing a greater role than the right.

Type
Review Articles
Information
Canadian Journal of Neurological Sciences , Volume 24 , Issue 4 , November 1997 , pp. 284 - 291
Copyright
Copyright © Canadian Neurological Sciences Federation 1997

References

REFERENCES

1.Rao, SM, Binder, JR, Bandettini, PA, et al. Functional magnetic resonance imaging of complex human movements. Neurology 1993; 43:2311–2318.CrossRefGoogle ScholarPubMed
2.Shibasaki, H, Sadato, N, Lyshkow, H, et al. Both primary motor cortex and supplementary motor area play an important role in complex finger movement. Brain 1993; 116: 1387–1398.CrossRefGoogle ScholarPubMed
3.Kim, S-G, Ashe, J, Georgopoulos, AP, et al. Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 1993; 69: 297–302.CrossRefGoogle ScholarPubMed
4.Sadato, N, Cambell, G, Ibáñez, V, Deiber, M-P, Hallett, M. Complexity affects regional cerebral blood flow change during sequential finger movements. J Neurosci 1996; 16: 2693–2700.CrossRefGoogle ScholarPubMed
5.Neshige, R, Lüders, H, Shibasaki, H. Recording of movement-related potentials from scalp and cortex in man. Brain 1988; 111: 719–736.Google ScholarPubMed
6.Pulvermuller, F, Lutzenberger, W, Preißl, H, Birbaumer, N. Motor programming in both hemispheres: an EEG study of the human brain. Neurosci Lett 1995; 190: 5–8.CrossRefGoogle ScholarPubMed
7.Kitamura, J-i, Shibasaki, H, Takagi, A, Nabeshima, H, Yamaguchi, A. Enhanced negative slope of cortical potentialś before sequential as compared with simultaneous extensions of two fingers. Electroencephalogr Clin Neurophysiol 1993; 86: 176–182.CrossRefGoogle ScholarPubMed
8.Brinkman, J, Kuypers, HGJM. Cerebral control of contralateral and ipsilateral arm, hand and finger movements in the split-brain rhesus monkey. Brain 1973; 96: 653–674.CrossRefGoogle ScholarPubMed
9.Lemon, RN. Stroke recovery. Curr Biol 1993; 3: 463–465.CrossRefGoogle ScholarPubMed
10.Palmer, E, Ashby, P, Hajek, VE. Ipsilateral fast corticospinal pathways do not account for recovery in stroke. Ann Neurol 1992; 32:519–525.CrossRefGoogle Scholar
11.Lee, RG, van Donkelaar, P. Mechanisms underlying functional recovery following stroke. Can J Neurol Sci 1995; 22: 257–263.CrossRefGoogle ScholarPubMed
12.Barker, AT, Jalinous, R, Freeston, IL. Non-invasive stimulation of the human motor cortex. Lancet 1985; 2: 1106–1107.CrossRefGoogle Scholar
13.Rothwell, JC, Thompson, PD, Day, BL, Boyd, S, Marsden, CD. Stimulation of the human motor cortex through the scalp. Exp Physiol 1991; 76: 159–200.CrossRefGoogle ScholarPubMed
14.Amassian, VE, Cracco, RQ, Maccabee, PJ, et al. Suppression of visual perception by magnetic coil stimulation of human occipital cortex. Electroencephalogr Clin Neurophysiol 1989; 74: 458–462.CrossRefGoogle ScholarPubMed
15.Cohen, LG, Bandinelli, S, Sato, S, Kufta, C, Hallett, M. Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1991; 81:366–376.CrossRefGoogle ScholarPubMed
16.Pascual-Leone, A, Gates, JR, Dhuna, A. Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation. Neurology 1991; 41: 697–702.CrossRefGoogle ScholarPubMed
17.Grafman, J, Pascual-Leone, A, Alway, D, et al. Induction of a recall deficit by rapid-rate transcranial magnetic stimulation. NeuroReport 1994; 5: 1157–1160.CrossRefGoogle ScholarPubMed
18.Chen, R, Gerloff, C, Hallett, M, Cohen, LG. Involvement of the ipsilateral motor cortex in finger movements of different complexities. Ann Neurol 1997; 41: 247–254.CrossRefGoogle ScholarPubMed
19.Wassermann, EM, Fuhr, P, Cohen, LG, Hallett, M. Effects of transcranial magnetic stimulation on ipsilateral muscles. Neurology 1991; 41: 1795–1799.CrossRefGoogle ScholarPubMed
20.Ferbert, A, Priori, A, Rothwell, JC, et al. Interhemispheric inhibition of the human motor cortex. J Physiol (Lond) 1992; 453: 525–546.CrossRefGoogle ScholarPubMed
21.Gerloff, C, Cohen, LG, Chen, R, et al. Modulatory influence of primary motor cortex on ipsilateral upper extremity. Neurology 1996;46(Suppl):A343.Google Scholar
22.Nyberg-Hansen, R, Rinvik, E. Some comments on the pyramidal tract, with special reference to its individual variations in man. Acta Neurol Scand 1963; 39: 1–30.CrossRefGoogle Scholar
23.Davidoff, RA. The pyramidal tract. Neurology 1990; 40: 332–339.CrossRefGoogle ScholarPubMed
24.Wassermann, EM, Pascual-Leone, A, Hallett, M. Cortical motor representation of the ipsilateral hand and arm. Exp Brain Res 1994; 100: 121–132.CrossRefGoogle ScholarPubMed
25.Hallett, M. Transcranial magnetic stimulation. Negative effects. In: Fahn, S, Hallett, M, Lüders, HO, Marsden, CD, eds. Negative Motor Phenomena. Advances in Neurology, v. 67. Philadelphia: Lippincott-Raven Publishers, 1995: 107–113.Google Scholar
26.Carr, LJ, Harrison, LM, Stephens, JA. Evidence for bilateral innervation of certain homologous motoneurone pools in man. J Physiol (Lond) 1994; 475: 217–227.CrossRefGoogle ScholarPubMed
27.Colebatch, JG, Gandevia, SC. The distribution of muscular weakness in upper motor neurone lesions affecting the arm. Brain 1989; 112:749–763.CrossRefGoogle ScholarPubMed
28.Fisher, CM. Concerning the mechanism of recovery in stroke hemiplegia. Can J Neurol Sci 1992; 19: 57–63.CrossRefGoogle ScholarPubMed
29.Silvestrini, M, Troisi, E, Matteis, M, Cupini, LM, Caltagirone, C. Involvement of the healthy hemisphere in recovery from aphasia and motor deficit in patients with cortical ischemic infarction: a transcranial doppler study. Neurology 1995; 45: 1815–1820.CrossRefGoogle ScholarPubMed
30.Chollet, F, DiPiero, V, Wise, RJS, et al. The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol 1991; 29: 63–71.CrossRefGoogle ScholarPubMed
31.Weiller, C, Chollet, F, Friston, KJ, Wise, RJS, Frackowiak, RSJ. Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol 1992; 31: 463–472.CrossRefGoogle ScholarPubMed
32.Weiller, C, Ramsay, SC, Wise, RJS, Friston, KJ, Frackowiak, RSJ. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol 1993; 33: 181–189.CrossRefGoogle ScholarPubMed
33.Benecke, R, Meyer, B-U, Freund, H-J. Reorganisation of descending motor pathways in patients after hemispherectomy and severe hemispheric lesions demonstrated by magnetic brain stimulation. Exp Brain Res 1991; 83: 419–426.CrossRefGoogle ScholarPubMed
34.Cohen, LG, Zeffiro, T, Bookheimer, S, et al. Reorganization in motor pathways following a large congenital hemispheric lesion in man: different motor representation areas for ipsi- and contralateral muscles. J Physiol (Lond) 1991; 438: 33P.Google Scholar
35.Hallett, M, Cohen, LG, Pascual-Leone, A, et al. Plasticity of the human motor cortex. In: Thilmann, AF, Burke, DJ, Rymer, WZ, eds. Spasticity. Mechanism and Management. Berlin: Springer-Verlag, 1993:67–81.CrossRefGoogle Scholar
36.Carr, LJ, Harrison, LM, Evans, AL, Stephens, JA. Patterns of central motor organization in hemiplegic cerebral palsy. Brain 1993; 116: 1223–1247.CrossRefGoogle Scholar
37.Turton, A, Wroe, S, Trepte, N, Fraser, C, Lemon, RN. Contralateral and ipsilateral EMG responses to transcranial magnetic stimulation during recovery of arm and hand function after stroke. Electroencephalogr Clin Neurophysiol 1996; 101: 316–328.CrossRefGoogle ScholarPubMed
38.Caramia, MD, Iani, C, Bernardi, G. Cerebral plasticity after stroke as revealed by ipsilateral responses to magnetic stimulation. NeuroReport 1996; 7: 1756–1760.CrossRefGoogle ScholarPubMed
39.Tanji, J, Okano, K, Sato, KC. Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey. J Neurophysiol 1988; 60: 325–343.CrossRefGoogle ScholarPubMed
40.Aizawa, H, Mushiake, H, Inase, M, Tanji, J. An output zone of the monkey primary motor cortex specialized for bilateral hand movement. Exp Brain Res 1990; 82: 219–221.CrossRefGoogle ScholarPubMed
41.Matsunami, K, Hamada, I. Characteristics of the ipsilateral movement-related neuron in the motor cortex in the monkey. Brain Res 1981; 204: 29–42.CrossRefGoogle ScholarPubMed
42.Kim, S-G, Ashe, J, Hendrich, K, et al. Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science 1993; 261: 615–617.CrossRefGoogle ScholarPubMed
43.Dassonville, P, Zhu, X-H, Kim, S-G, Ugurbil, K, Ashe, J. Difference in the functional lateralization of cortical motor areas during finger movements. Soc Neurosci Abst 1996; 22: 657.Google Scholar
44.Boecker, H, Kleinschmidt, A, Requardt, M, et al. Functional cooperativity of human cortical motor areas during self-paced simple finger movements. A high-resolution MRI study. Brain 1994; 117: 1231–1239.Google ScholarPubMed
45.Roland, PE, Larsen, B, Lassen, NA, Shinkoj, E. Supplementary motor area and other cortical areas in organization of voluntary movements in man. J Neurophysiol 1980; 43: 118–136.CrossRefGoogle ScholarPubMed
46.Roland, PE, Shinhoj, E, Lassen, NA, Larsen, B. Different cortical areas in man in organization of voluntary movements in extrapersonal space. J Neurophysiol 1980; 43: 137–150.CrossRefGoogle ScholarPubMed
47.Colebatch, JG, Deiber, M-P, Passingham, RE, Friston, KJ, Frackowiak, RSJ. Regional cerebral blood flow during voluntary arm and hand movements in human subjects. J Neurophysiol 1991; 65: 1392–1401.CrossRefGoogle ScholarPubMed
48.Hopf, HC, Schlegel, HJ, Lowitzsch, K. Irradiation of voluntary activity to the contralateral side in movements of normal subjects and patients with central motor disturbances. Eur Neurol 1974; 12: 142–147.CrossRefGoogle Scholar
49.Forget, R, Boghen, D, Attig, E, Lamarre, Y. Electromyographic studies of congenital mirror movements. Neurology 1986; 36: 1316–1322.CrossRefGoogle ScholarPubMed
50.Mayer, M, Bötzel, K, Paulus, W, et al. Movement-related cortical potentials in persistent mirror movements. Electroencephalogr Clin Neurophysiol 1995; 95: 350–358.CrossRefGoogle ScholarPubMed
51.Neshige, R, Lüders, H, Friedman, L, Shibasaki, H. Recording of movement-related potentials from the human cortex. Ann Neurol 1988; 24: 439–445.CrossRefGoogle ScholarPubMed
52.Ikeda, A, Lüders, HO, Burgress, RC, Shibasaki, H. Movement-related potentials recorded from supplementary motor area and primary motor area. Role of supplementary motor area in voluntary movements. Brain 1992; 115: 1017–1043.CrossRefGoogle ScholarPubMed
53.Ikeda, A, Lüders, HO, Shibasaki, H, et al. Movement-related potentials associated with bilateral simultaneous and unilateral movements recorded from human supplementary motor area. Electroencephalogr Clin Neurophysiol 1995; 95: 323–334.CrossRefGoogle ScholarPubMed
54.Toro, C, Deuschl, G, Thatcher, R, et al. Event-related desynchronization and movement-related cortical potentials on the ECoG and EEG. Electroencephalogr Clin Neurophysiol 1994; 93: 380–389.CrossRefGoogle ScholarPubMed
55.Brodal, A. Self-observation and neuro-anatomical considerations after stroke. Brain 1973; 96: 675–694.CrossRefGoogle Scholar
56.Jones, RD, Donaldson, IM, Parkin, PJ. Impairment and recovery of ipsilateral sensory-motor function following unilateral cerebral infarction. Brain 1989; 112: 113–132.CrossRefGoogle ScholarPubMed
57.Geffen, GM, Jones, DL, Geffen, LB. Interhemispheric control of manual motor activity. Behav Brain Res 1994; 64: 131–140.CrossRefGoogle ScholarPubMed
58.Wyke, M. The effects of brain lesions on the performance of bilateral arm movements. Neuropsychologia 1971; 9: 33–42.CrossRefGoogle ScholarPubMed
59.Kimura, D. Acquisition of motor skill after left-hemisphere damage. Brain 1977; 100: 527–542.CrossRefGoogle ScholarPubMed
60.Vaughan, HG, Costa, LD. Performance of patients with lateralized cerebral lesions. II. Sensory and motor tests. J Nerv Ment Dis 1962; 134: 237–243.CrossRefGoogle ScholarPubMed
61.Harrington, DL, Haaland, KY. Motor sequencing with left hemisphere damage: are some cognitive deficits specific to limb apraxia? Brain 1992; 115: 857–874.CrossRefGoogle ScholarPubMed
62.Hammond, GR. Hemispheric differences in temporal resolution. Brain Cogn 1982; 1:95–118.CrossRefGoogle ScholarPubMed
63.Haaland, KY, Harrington, DL. Limb-sequencing deficits after left but not right hemispheric damage. Brain Cogn 1994; 24: 104–122.CrossRefGoogle ScholarPubMed
64.Haaland, KY, Harrington, DL, Yeo, RA. The effects of task complexity on motor performance in left and right CVA patients. Neuropsychologia 1987; 25: 783–794.CrossRefGoogle ScholarPubMed
65.Kimura, D, Archibald, Y. Motor functions of the left hemisphere. Brain 1974; 97: 337–350.CrossRefGoogle ScholarPubMed
66.Asanuma, H. The Motor Cortex. New York: Raven Press, 1989.Google ScholarPubMed
67.Alexander, GE, Crutcher, MD. Preparation of movement: neural representations of intended direction in three motor areas of the monkey. J Neurophysiol 1990; 64: 133–150.CrossRefGoogle ScholarPubMed
68.Alexander, GE, Crutcher, MD. Neural representation of the target (goal) of visually guided arm movements in three motor areas in monkey. J Neurophysiol 1990; 64: 164–178.CrossRefGoogle ScholarPubMed
69.Georgopoulos, A, Lurito, JT, Petrides, M, Schwartz, AB, Massey, JT. Mental rotation of the neuronal population vector. Science 1989; 243: 234–236.CrossRefGoogle ScholarPubMed
70.Hoffman, DS, Strick, PL. Effects of a primary motor cortex lesion on step-tracking movements of the wrist. J Neurophysiol 1995; 73: 891–895.CrossRefGoogle ScholarPubMed
71.Pascual-Leone, A, Graf man, J, Hallett, M. Modulation of cortical motor output maps during development of implicit and explicit knowledge. Science 1994; 263: 1287–1289.CrossRefGoogle ScholarPubMed
72.Pascual-Leone, A, Dang, N, Cohen, LG, et al. Modulation of muscle responses evoked by transcranial magnetic stimulation during acquisition of new fine motor-skills. J Neurophysiol 1995; 74: 1037–1045.CrossRefGoogle ScholarPubMed
73.Kami, A, Meyer, G, Jezzard, P, et al. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 1995;377: 155–158.CrossRefGoogle Scholar
74.Corwell, B, Gerloff, C, Deiber, M-P, et al. Different involvement of primary motor cortex with increasing complexity of motor tasks. Neurology 1996; 46: A398.Google Scholar