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Ribonuclease Activity of Human Cerebrospinal Fluid

Published online by Cambridge University Press:  15 November 2018

E. Z. Rabin ,
V. Weinberger  and
B. Tattrie
E. Z. Rabin*
Affiliation:
Montreal General Hospital, McGill University, Montreal, Quebec and Division of Nephrology, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada
V. Weinberger
Affiliation:
Montreal General Hospital, McGill University, Montreal, Quebec and Division of Nephrology, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada
B. Tattrie
Affiliation:
Montreal General Hospital, McGill University, Montreal, Quebec and Division of Nephrology, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario, Canada
*
Division of Nephrology, Ottawa Civic Hospital, 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada
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Summary

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The ribonuclease activity of cerebrospinal fluid of 219 patients was studied. The normal level was 269 ±95 units/ml. Consistent elevations above 550 units/ml were found in. 1 Chronic cerebrovascular disease, 2 Spinal cord compression; 3. Tumors. The molecular weights of the ribonucleases in the cerebrospinal fluid are approximately 33,000; 21,000 and 15,000, the major species is the one with m w. 33,000.

Although the increase in the CSF ribonuclease activity is not disease specific, the measurement has provided corroborative help in cases when the CSF protein is normal.

The increase in CSF RNAase is not due to red or white blood cells and the immunologie data suggest that the CSF enzyme activity is derived from the blood stream Further studies are necessary to rule out a nerve cell origin of the CSF ribonuclease activity.

Résumé

Résumé

L’activité de la ribonucléase du liquide céphalorachidien de 219 patients fut étudiée Le niveau normal est de 269 ± 95 unités/ml. Des élévations constantes au-dessus de 550 unités/ml furent trouvées dans. 1) la maladie cérébro-vasculaire chronique; 2) la compression de la moëlle épiniére; 3) les tumeurs. Les poids moléculaires des ribonucléases dans le liquide céphalo-rachidien sont approximativement de l’ordre de 33,000; 21,000 et 15,000; la principale molécule a un poids moléculaire de 33,000.

Quoique l’augmentation de l’activité de la ribonucléase dans le LCR n’est pas spécifique à une maladie, cette mesure a fourni une aide supplémentaire dans les cas où les protéines du LCR sont normales.

L’augmentation de RNAase dans le LCR n’est pas dûe aux globules blancs ou rouges et les données immunologiques nous portent à croire que l’activité enzyniatique du LCR est dérivée de la circulation sanguine D’autres études sont nécessaires pour prouver une origine à partir des cellules nerveuses de l’activité de la ribonucléase du LCR.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 2 , May 1977 , pp. 125 - 130
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

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