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Regional Metal Concentrations in Parkinson's Disease, Other Chronic Neurological Diseases, and Control Brains

Published online by Cambridge University Press:  18 September 2015

Ryan J. Uitti ,
A.H. Rajput ,
B. Rozdilsky ,
M. Bickis ,
T. Wollin  and
W.K. Yuen
Ryan J. Uitti
Affiliation:
Department of Clinical Neurological Sciences, Saskatoon
A.H. Rajput*
Affiliation:
Department of Clinical Neurological Sciences, Saskatoon
B. Rozdilsky
Affiliation:
Department of Pathology, Saskatoon
M. Bickis
Affiliation:
Department of Mathematics and Statistics, Saskatoon
T. Wollin
Affiliation:
Department of Clinical Neurological Sciences, Saskatoon
W.K. Yuen
Affiliation:
University of Saskatchewan, and the Saskatchewan Research Council, Saskatoon
*
Dept. of Clinical Neurological Sciences, University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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Metal deficiency or toxicity states have been recognized as a cause of several neurological disorders and are suspected in others. We analyzed four brain regions (frontal cortex, caudate nucleus, substantia nigra, and cerebellum) in 36 human brains for concentrations of 24 metals (Ag, Al, As, B, Be, Ca, Cd, Co, Cr, Cu, Fe, K, Pb, Mg, Mn, Mo, Na, Ni, P, Se, Ti, V, W, Zn). Regional metal concentrations, measured using atomic absorption and atomic emission spectroscopy, were compared between 9 Parkinson's disease (PD) brains, 15 brains from patients with other chronic neurological diseases, and 12 control brains. No significant metal concentration differences were noted between brains from PD and other chronic neurologic disease. However, parkinsonian brains (PD and parkinsonism secondary to neurofibrillary tangle disease) showed lower concentrations of magnesium in the caudate nucleus and copper in the substantia nigra than control brains. These findings may represent an etiologically important clue to parkinsonism.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 3 , August 1989 , pp. 310 - 314
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

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