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Regional Distribution of Amino Acids in Friedreich's Ataxia Brains

Published online by Cambridge University Press:  18 September 2015

R. Huxtable ,
J. Azari ,
T. Reisine ,
P. Johnson ,
H. Yamamura  and
A. Barbeau
R. Huxtable
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
J. Azari
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
T. Reisine
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
P. Johnson
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
H. Yamamura
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
the Departments of Pharmacology and Pathology, University of Arizona Health Sciences Center, Tucson and the Clinical Research Institute of Montreal
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Summary

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The distribution of amino acids in two Friedreich's ataxia brains is compared to 4 control brains. Glutamate and G A BA were decreased in the ce r ebe l-lar hemispheres and/or in the vermis. Taurine concentrations were uniformly elevated throughout the areas studied. Taurine /glutamate and taurine/ GABA ratios were consistently elevated in Friedreich's ataxia brains, whereas glutamate/ glutaminę ratios were consistently decreased (with normal glutaminę concentrations).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 255 - 258
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

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