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Real Time Operations of the Cerebellar Cortex

Published online by Cambridge University Press:  18 September 2015

R. Bloedel James ,
Bracha Vlastislav  and
S. Larson Paul
R. Bloedel James*
Affiliation:
Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona
Bracha Vlastislav*
Affiliation:
Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona
S. Larson Paul*
Affiliation:
Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, 350 West Thomas Road, Phoenix, Arizona
*
Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona, U.S.A. 85013
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Abstract:

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This manuscript reviews a series of experiments which support the notion that the cerebellum and more specifically the cerebellar cortex is principally involved in real time operations required for the regulation of coordinated motor activity. Experiments are reviewed which illustrate: (1) that the climbing fiber inputs to Purkinje cells can induce a short-lasting enhancement of their responses to mossy fiber-granule cell-parallel fiber inputs, (2) that the cerebellum is not essential for the acquisition and performance of the classically conditioned nictitating membrane reflex (NMR) of the rabbit, and (3) that the observations resulting from the microinjection of lidocaine and multiple single unit recordings within the brainstem support the notion that cell populations in this region may participate in establishing the modifications in neuronal interactions required for the acquisition of the conditioned NMR. In addition, preliminary data are shown comparing the capacity of a normal subject and a patient with a massive ipsilateral cerebellar stroke to learn certain tracing tasks and to redraw these learned tracing movements 90° to the orientation of the original image. The data support the notion that the cerebellum is essential, not for the initial learning of the tracing movement, but rather for performing the learned movement with the required rotation of the original image.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S7 - S18
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Ito, M.The cerebellar control of the vestibulo-ocular reflex around the flocculus hypothesis. Ann Rev Neurosci 1982; 5: 275–296.CrossRefGoogle ScholarPubMed
2.Ito, M.The role of the cerebellum during motor learning in the vestibular reflex: different mechanisms and different species. Trends Neurosci 1982; 5: 416.CrossRefGoogle Scholar
3.McCormick, DA, Thompson, RF.Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J Neurosci 1984; 4: 2811–2822.CrossRefGoogle ScholarPubMed
4.Thompson, RF.The neurobiology of learning and memory. Science 1986; 223: 941–947.Google Scholar
5.Yeo, CH, Hardiman, MJ, Glickstein, M.Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex. Exp BrainRes 1985; 60: 99–113.CrossRefGoogle ScholarPubMed
6.Yeo, CH, Hardiman, MJ, Glickstein, M.Classical conditioning of the nictitating membrane response of the rabbit. I. Lesions of the cerebellar nuclei. Exp Brain Res 1985; 60: 87–98.CrossRefGoogle ScholarPubMed
7.Bloedel, JR.Functional heterogeneity with structural homogeneity: how does the cerebellum operate? Behav Brain Sci 1992: in press.Google Scholar
8.Wilson, VJ, Yamagata, Y, Yates, BJ, et al.Response of vestibular neurons to head rotations in vertical planes. III. Response of vestibulocollic neurons to vestibular and neck stimulation. J Neurophysiol 1990; 64: 1695–1703.CrossRefGoogle ScholarPubMed
9.McCormick, DA, Thompson, RF.Cerebellum: essential involvement in the classically conditioned eyelid response. Science 1984; 223: 296–299.CrossRefGoogle ScholarPubMed
10.Crepel, F, Jaillard, D.Pairing of pre- and post-synaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro. J Physiol 1991; 432: 123–141.CrossRefGoogle Scholar
11.Sakurai, M.Synaptic modification of parallel fiber – Purkinje cell transmission in in vitro guinea pig cerebellar slices. J Physiol 1987: 394: 463–480.CrossRefGoogle Scholar
12.Knowlton, BJ, Lavond, DG, Thompson, RF.The effect of lesions of cerebellar cortex on retention of the classically conditioned eyeblink response when stimulation of the lateral reticular nucleus is used as the conditioned stimulus. Behav Neural Biol 1988; 49: 293–301.CrossRefGoogle ScholarPubMed
13.Lavond, DG, Knowlton, BJ, Steinmetz, JE, et al.Classical conditioning of the rabbit eyelid response with mossy fiber stimulation as a CS. II. Lateral reticular nucleus stimulation. Behav Neurosci 1987; 101: 676–682.CrossRefGoogle Scholar
14.Mauk, MD, Steinmetz, JE, Thompson, RF.Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc Natl Acad Sci USA 1986; 83: 5349–5353.CrossRefGoogle ScholarPubMed
15.Steinmetz, JE, Lavond, DG, Thompson, RF.Classical conditioning of the rabbit eyelid response with mossy fiber stimulation as the conditioned stimulus. Bull Psychon 1985; 23: 245–248.CrossRefGoogle Scholar
16.Sanes, JN, Dimitrov, B, Hallett, M.Motor learning in patients with cerebellar dysfunction. Brain 1990; 113: 103–120.CrossRefGoogle ScholarPubMed
17.Ebner, TJ, Bloedel, JR.Role of climbing fiber afferent input in determining the responsiveness of Purkinje cells to mossy fiber inputs. J Neurophysiol 1981; 45: 962–971.CrossRefGoogle ScholarPubMed
18.Schwartz, AB, Ebner, TJ, Bloedel, JR.Comparison of responses in dentate and interposed nuclei to perturbations of the locomotor cycle. Exp Brain Res 1987; 67: 323–338.CrossRefGoogle Scholar
19.Lou, J-S, Bloedel, JR.The responses of simultaneously recorded Purkinje cells to perturbations of the step cycle in the walking ferret: a study using a new analytical method – the real time postsynaptic response (RTPR). Brain Res 1986; 365: 340–344.CrossRefGoogle Scholar
20.Ebner, TJ, Yu, Q-X, Bloedel, JR.Increase in Purkinje cell gain associated with naturally activated climbing fiber inputs. J Neuro-physiol 1983; 50: 205–219.Google Scholar
21.Ebner, TJ, Bloedel, JR.Climbing fiber action on the responsiveness of Purkinje cells to parallel fiber inputs. Brain Res 1984; 309: 182–186.CrossRefGoogle ScholarPubMed
22.Bloedel, JR, Ebner, TJ, Yu, Q-X.Increased responsiveness of Purkinje cells associated with climbing fiber inputs to neighboring neurons. J Neurophysiol 1983; 50: 220–239.CrossRefGoogle ScholarPubMed
23.Kelly, TM, Zuo, C-C, Bloedel, JR.Classical conditioning of the eyeblink reflex in the decerebrate-decerebellate rabbit. Behav Brain Res 1990; 38: 7–18.CrossRefGoogle ScholarPubMed
24.Bracha, V, Wu, J-Z, Cartwright, S, et al.Selective involvement of the spinal trigeminal nucleus in the conditioned nictitating membrane reflex of the rabbit. Brain Res 1991; 556: 317–320.CrossRefGoogle ScholarPubMed
25.Miller, S, Van der Burg, J, Van der Meche, FGA.Locomotion in the cat: basic programmers of movement. Brain Res 1975; 91: 239–253.CrossRefGoogle ScholarPubMed
26.Desmond, JE, Moore, JW.A supratrigeminal region implicated in the classically conditioned nictitating membrane response. Brain ResBull 1983; 10: 765–773.Google ScholarPubMed
27.Bracha, V, Cartwright, M, Bloedel, JR.Multiple single unit recording during the conditioning of the nictitating membrane reflex in the rabbit. Proc Third IBRO World Congress 1991: 173 (Abstract).Google Scholar
28.Chan, CY, Hounsgaard, J, Midtgaard, J.Excitatory synaptic responses in turtle cerebellar Purkinje cells. J Physiol 1989; 409: 143–156.CrossRefGoogle ScholarPubMed
29.Bloedel, JR, Ebner, TJ.Climbing fiber function: regulation of Purkinje cell responsiveness. In: Bloedel, JR, Dichgans, J, Precht, W, eds. Cerebellar Functions. Berlin, Heidelberg, New York: Springer-Verlag, 1985: 247–259.CrossRefGoogle Scholar
30.Bloedel, JR, Zuo, C-C.The heterosynaptic action of climbing fibers in the cerebellar cortex. Exp Brain Res 17 1989; 246–264.Google Scholar
31.Bloedel, JR, Kelly, TM.The Dynamic Selection Hypothesis: A Proposed Function for Cerebellar Sagittal Zones. In: Llinas, R, Soleto, C, eds. The Cerebellum Revisited. New York: Springer-Verlag, 1992: 267–282.CrossRefGoogle Scholar
32.Groenewegen, HJ, Voogd, J.The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of cat cerebellum. J Comp Neurol 1977; 174: 417–488.CrossRefGoogle ScholarPubMed
33.Groenewegen, HJ, Voogd, J, Freedman, SL.The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric parts of cat cerebellum. J Comp Neurol 1979; 183:551–602.CrossRefGoogle ScholarPubMed
34.Voogd, J, Bigare, F.Topographical distribution of olivary and cortico nuclear fibers in the cerebellum: a review. In: Courville, J, de Montigny, C, Lamarre, Y, eds. The Inferior Olivary Nucleus: Anatomy and Physiology. New York: Raven Press, 1980: 207–234.Google Scholar
35.Shambes, GM, Gibson, JM, Welker, W.Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping. Brain Behav Evol 1978; 15: 94–140.CrossRefGoogle ScholarPubMed
36.Welsh, JP, Harvey, JA.Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J Neurosci 1989; 9: 299–311.CrossRefGoogle ScholarPubMed
37.Welsh, JP, Harvey, JA.Pavlovian conditioning in the rabbit during inactivation of the interpositus nucleus. J Physiol 1991; 444: 459–480.CrossRefGoogle ScholarPubMed
38.Nordholm, AF, Lavond, DG, Thompson, RF.Are eyeblink responses to tone in the decerebrate, decerebellate rabbit conditioned responses? Behav Brain Res 1991; 44: 27–34.CrossRefGoogle ScholarPubMed
39.Akase, E, Alkon, DL, Disterhoft, JF.Hippocampal lesions impair memory of short-delay conditioned eyeblink in rabbit. Behav Neurosci 1989; 103: 935–943.CrossRefGoogle Scholar
40.Megirian, D, Bures, J.Unilateral cortical spreading depression and conditioned eyeblink responses in the rabbit. Exp Neurol 1970; 27: 34–45.CrossRefGoogle ScholarPubMed
41.Moyer, J.R. Jr, Deyo, RA, Disterhoft, JF.Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav Neurosci 1990; 104: 243–252.CrossRefGoogle Scholar
42.Oakley, DA, Russell, ISSubcortical nature of Pavlovian differentiation in the rabbit. Physiol Behav 1976; 17: 947–954.CrossRefGoogle ScholarPubMed
43.Salafia, WR, Nicolas, LC, Ramirez, JJ.Retardation of rabbit nictitating membrane conditioning by subseizure electrical stimulation of hippocampus. Physiol Behav 1979; 22: 451–455.CrossRefGoogle ScholarPubMed
44.Pellionisz, A, Llinas, R.Tensor network theory of the metaorganization of functional geometries in the central nervous system. Neuroscience 1985; 16: 245–273.CrossRefGoogle ScholarPubMed
45.Pellionisz, AJ.Tensorial brain theory in cerebellar modelling. In: Bloedel, JR, Dichgans, J, Precht, W, eds. Cerebellar Functions. Berlin, Heidelberg, New York, Tokyo: Springer-Verlag, 1985: 201–229.Google Scholar
46.Lestienne, F, Gurfinkel, VS.Posture as an organizational structure based on a dual process: a formal basis to interpret changes of posture in weightlessness. In: Pompeiano, Allum J, eds. Vestibulospinal control of posture and locomotion. Prog Brain Res 1988; 76: 307–313.CrossRefGoogle ScholarPubMed
47.Beppu, H, Nagaoka, M, Tanaka, R.Analysis of cerebellar motor disorders by visually-guided elbow tracking movement. Brain 1987; 110: 1–18.CrossRefGoogle ScholarPubMed
48.Beppu, H, Suda, M, Tanaka, R.Analysis of cerebellar motor disorders by visually guided elbow tracking movement. Brain 1984; 107: 787–809.CrossRefGoogle ScholarPubMed
49.Vercher, J-L, Gauthier, GM, Cerebellar involvement in the coordination control of the oculo-manual tracking system: effects of cerebellar dentate nucleus lesion. Exp Brain Res 1988; 73: 155–166.CrossRefGoogle ScholarPubMed