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Quantitative Metabolic Profiling of α -Keto Acids in Friedreich’s Ataxia

Published online by Cambridge University Press:  18 September 2015

M.J. Bertrand ,
R. Bouchard ,
G.L. Gauthier ,
J.P. Bouchard  and
A. Barbeau
M.J. Bertrand
Affiliation:
Departement of Chemistry, Université de Montréal
R. Bouchard
Affiliation:
l’Hôpital de l’Enfant-Jèsus, Québec
G.L. Gauthier
Affiliation:
Departement of Chemistry, Université de Montréal
J.P. Bouchard
Affiliation:
l’Hôpital de l’Enfant-Jèsus, Québec
A. Barbeau*
Affiliation:
l’Institut de recherches cliniques de Montréal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montréal, Quebec, Canada, H2W 1R7
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The plasma distribution of α-keto acids was measured in 26 subjects including 8 patients with Friedreich’s ataxia, 8 with the recessive spastic ataxia of Charlevoix-Saguenay and 10 healthy volunteers. The groups were matched with regards to age, sex, weight and the study was conducted under standardized dietary intake. The results indicate significant differences in α-keto acids distribution between the groups.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 231 - 234
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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