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Quantitative evaluation of the effects of acetazolamide in Friedreich's ataxia: A pilot study

Published online by Cambridge University Press:  18 September 2015

C.L. Richards ,
J.P. Bouchard ,
F. Dumas  and
D. Tardif
C.L. Richards
Affiliation:
Centre de Recherche en Neurobiologie, Département des Sciences Neurologiques, Hôpital de l'Enfant-Jésus and Ecole de Réadaptation, Université Laval
J.P. Bouchard
Affiliation:
Centre de Recherche en Neurobiologie, Département des Sciences Neurologiques, Hôpital de l'Enfant-Jésus and Ecole de Réadaptation, Université Laval
F. Dumas
Affiliation:
Centre de Recherche en Neurobiologie, Département des Sciences Neurologiques, Hôpital de l'Enfant-Jésus and Ecole de Réadaptation, Université Laval
D. Tardif
Affiliation:
Centre de Recherche en Neurobiologie, Département des Sciences Neurologiques, Hôpital de l'Enfant-Jésus and Ecole de Réadaptation, Université Laval
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Abstract

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We evaluated the effects of acetazolamide in 4 young patients with Friedreich's ataxia by clinical and quantitative laboratory methods. Dynamic muscle function of the lower extremity was measured during isokinetic knee movements and gait. The acetazolamide trial was terminated at 7 to 11 weeks because of reported side effects or increased ataxia in 3 of the patients. The quantitative evaluations revealed lower dynamic strength values and alterations in the gait movement pattern in all patients. These changes, which were interpreted as deterioration, were partially reversible with cessation of acetazolamide. The advantages of such quantitative evaluations of dynamic muscle function in the evaluation of therapy in Friedreich's ataxia are discussed.

Type
A—Clinical Studies
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 554 - 560
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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