Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-28T19:42:16.758Z Has data issue: false hasContentIssue false
  • English
  • Français

Prior Intra-operative Hypotension is not a Risk Factor for Development of Alzheimer’s Disease

Published online by Cambridge University Press:  18 September 2015

N.I. Bohnen ,
E.F.M. Wijdicks ,
E. Kokmen ,
M.A. Warner  and
L.T. Kurland
N.I. Bohnen*
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
E.F.M. Wijdicks
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
E. Kokmen
Affiliation:
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
M.A. Warner
Affiliation:
Department of Anesthesiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
L.T. Kurland
Affiliation:
Health Sciences Research, Section of Clinical Epidemiology, Mayo Clinic/Mayo Foundation, Rochester, Minnesota
*
Department of Neurology, Mayo Clinic. 200 First Street Southwest, Rochester, Minnesota 55905, USA
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

A retrospective, population-based, case-control study was carried out to evaluate episodes of prior intra-operative hypotension as a potential risk factor for Alzheimer’s disease (AD).

Methods:

Patients were all incident cases of AD from 1975–1984 who resided for 40 years or more in Olmsted County prior to their onset of dementia (N = 252). One age and gender-matched control for each case was selected from all registrations for care at Mayo Clinic during the year of onset in the incident case. Each case and control group had 252 individuals.

Results:

Of these, 27 cases and 32 controls had at least one ten minute or longer episode of intra-operative hypotension of a systolic blood pressure of less than 90 mm Hg prior to the year of onset of dementia in the matched AD patient. We did not find a significantly increased risk of AD for hypotensive episodes of less than 75 or 90 mm Hg.

Conclusions:

It is unlikely that intra-operative hypotensive events of this degree increase the risk of AD.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 23 , Issue 1 , February 1996 , pp. 57 - 58
Copyright
Copyright © Canadian Neurological Sciences Federation 1996

References

1.Hansen, MB, Bigler, DR.Changes in mental function after anesthesia and surgery. Ugeskrift für Laeger 1992; 154: 2000–2003.Google ScholarPubMed
2.Bohnen, NI, Kokmen, E, Warner, MA, Kurland, LT.Early and midlife exposure to anesthesia and age of onset of Alzheimer’s disease. Int J Neurosci 1994; 77: 181–185.CrossRefGoogle ScholarPubMed
3.Okazaki, H.Fundamentals of Neuropathology. Second edition. New York: Igaku-Shoin, 1989: 60.Google Scholar
4.Kokmen, E, Beard, CM, Chandra, V, et al. Clinical risk factors for Alzheimer’s disease. A population-based control study. Neurology 1991; 41: 1393–1397.CrossRefGoogle Scholar
5.SAS User’s guide. Statistics Version 6, Fourth Edition, Volume 1. Cary: North Carolina: SAS Institute Ine, 1989.Google Scholar
6.Cooper, JK, Mungas, D.Risk factor and behavioral differences between vascular and Alzheimer’s dementias: the pathway to end-stage disease. J Geriatr Psychiatr Neurol 1993; 6: 29–33.CrossRefGoogle ScholarPubMed
7.Román, GC, Tatemichi, TK, Erkinjuntti, T, et al. Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology 1993; 43: 250–260.CrossRefGoogle ScholarPubMed