Hostname: page-component-745bb68f8f-v2bm5 Total loading time: 0 Render date: 2025-01-22T19:12:59.691Z Has data issue: false hasContentIssue false
  • English
  • Français

Primary Lymphoma of the Central Nervous System: Manitoba Experience and Literature Review

Published online by Cambridge University Press:  18 September 2015

Douglas E. Hobson ,
Brian A. Anderson ,
Ian Carr  and
Michael West
Douglas E. Hobson
Affiliation:
Department of Medicine, University of Manitoba, Winnipeg
Brian A. Anderson*
Affiliation:
Department of Medicine, University of Manitoba, Winnipeg
Ian Carr
Affiliation:
Department of Pathology, University of Manitoba, Winnipeg
Michael West
Affiliation:
Department of Surgery, University of Manitoba, Winnipeg
*
Department of Medicine, St.Boniface Hospital, 409 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We describe eight cases of primary cerebral lymphoma seen in Manitoba from 1980 to 1985.

The clinical presentation is similar to other primary brain tumors. The diagnosis should be considered when single or multiple, often deep lesions, show dense enhancement on computerized tomographic (CT) scan, but are avascular at angiography. These tumors are histologically indistinguishable from non-Hodgkins lymphomas arising outside the CNS.

The prognosis is poor. However, radiotherapy with or without surgery may offer significant palliation. Although there is no consensus on the value of chemotherapy, corticosteroids alone or multiagent chemotherapy have shown promise in a few cases. For these reasons, histologic diagnosis should be sought in all cases and surgery, radiotherapy, and chemotherapy should be considered, as prolonged survival is possible.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 1 , February 1986 , pp. 55 - 61
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

REFERENCES

1.Jellinger, K, Radaskiewcz, T, Slowik, F. Primary malignant lymphomas of the central nervous system in man. Acta Neuropath (Berlin) 1975; Supp 6, 95–102.Google Scholar
2.Zimmerman, H. Malignant lymphomas of the nervous system. Acta Neuropath (Berlin) 1975; Supp 6, 69–74.Google Scholar
3.Schneck, S, Penn, I. Cerebral neoplasms associated with renal transplantation. Arch Neurol 1970; 22: 226–233.CrossRefGoogle ScholarPubMed
4.Scully, R, Mark, E, McNeely, B. Case records of the Massachusetts General Hospital, Case 32, 1983. New Eng J Med 1983; 309: 359–369.Google Scholar
5.Lipsmeyer, EA. Development of malignant cerebral lymphoma in a patient with systemic lupus erythematosis treated with immunosuppression. Arthritis Rheum 1972; 15: 183–186.CrossRefGoogle Scholar
6.Klassen, SS, Hoover, R, Kimberly, R, Budman, OR, Decker, JL, Chused, TM. Increased incidence of malignancy in Sjogren’s syndrome (SS)(Abstr) Arthritis Rheum 1977; 20: 123.Google Scholar
7.Good, EA, Russo, RH, Schnitzer, B, Weatherbee, L. Intracranial histiocytic lymphoma with rheumatoid arthritis. J Rheumatology 1978; 5: 75–78.Google ScholarPubMed
8.Gregory, MC, Hughes, JT. Intracranial reticulum cell sarcoma associated with immunoglobulin A deficiency. J Neurol Neurosurg Psychiat 1973; 36: 769–776.CrossRefGoogle ScholarPubMed
9.Mendenhall, NP, Thar, TL, Agee, OF, Harty-Golder, B, Ballinger, WE, Million, RR. Primary lymphoma of the CNS. Computerized tomography scan characteristics and treatment results for 12 cases. Cancer 1983; 52: 1993–2000.3.0.CO;2-C>CrossRefGoogle Scholar
10.Louie, S, Schwartz, RS. Immunodeficiency and the pathogenesis of lymphoma and leukemia. Semin Hematology 1978; 15: 117–138.Google ScholarPubMed
11.Helle, T, Britt, R, Colby, T. Primary lymphoma of the central nervous system — clinicopathologic study of experience of Stanford. J Neurosurgery 1984; 60: 94–103.CrossRefGoogle ScholarPubMed
12.Horvat, B, Pena, C, Fisher, E. Primary reticulum cell sarcoma (microglioma) of brain — an electron microscopic study. Arch Path 1969; Vol 87: 609–616.Google Scholar
13.Taylor, C, Russell, R, Lukes, R, David, R. An immunohistological study of immunoglobulin content of primary central nervous system lymphomas. Cancer 1978; 41: 2197–2205.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
14.Burnstein, S, Kernohan, J, Uihlein, A. Neoplasms of the reticuloendothelial system of the brain. Cancer 1963; 16: 290–305.Google Scholar
15.March, WL Jr, Stevenson, DR, Long, HJ. Primary leptomeningeal presentation of T-cell lymphoma. Report of a patient and review of the literature. Cancer 1983; 51: 1125–1131.Google Scholar
16.Schaumberg, H, Plank, C, Adams, R. The reticulum cell sarcomamicroglioma group of brain tumors. Brain 1972; 95: 199–212.CrossRefGoogle Scholar
17.Kazner, E, Wilske, J, Steinhoff, Het al. Computed assisted tomography in primary malignant lymphomas of the brain. J Comp Assist Tomography 1978; 2: 125–134.CrossRefGoogle ScholarPubMed
18.Enzmann, D, Krikorian, J, Norman, D, Kramer, R, Pollock, H, Faer, M. Computed tomography in primary reticulum cell sarcoma of the brain. Radiology 1979; 130: 165–170.CrossRefGoogle ScholarPubMed
19.Tallroth, K, Kateue, K, Hoist, L, Andersson, U. Angiography and computed tomography in the diagnosis of primary lymphoma of the brain. Clinical Radiology 1981; 32: 383–388.CrossRefGoogle ScholarPubMed
20.Thomson, J, Brownell, B. Computer tomographic appearances in microgliomatosis. Clinical Radiology 1981; 32: 367–374.CrossRefGoogle ScholarPubMed
21.Spillane, J, Kendal, B, Moseley, I. Cerebral lymphoma: clinical radiological correlation. J Neurol Neurosurg Psychiat 1982; 45: 199–208.CrossRefGoogle ScholarPubMed
22.Thomas, M, MacPherson, P. Computed tomography of intracranial lymphoma. Clinical Radiology 1982; 33: 331–336.CrossRefGoogle ScholarPubMed
23.Sagerman, RH, Cassaday, JR, Chang, CH. Radiation therapy for intracranial lymphoma. Radiology 1967; 88: 552–554.CrossRefGoogle ScholarPubMed
24.Jellinger, K. Primary lymphomas of the CNS. Arch Neurology 1982; 39: 458.CrossRefGoogle ScholarPubMed
25.Rappaport, H. Tumors of the hematopoietic system. In: “Atlas of tumor pathology”, 1966; Washington DC, Armed Forces Institute of Pathology, Section III, Fascicle 8, p. 99–101.Google Scholar
26.Robbins, SL, Cotran, RS, Kumar, V. Pathologic bases of disease, 1984; Chapter 15, Diseases of white cells, lymph nodes and spleen, 3rd edition, W.B.Saunders, p. 653–704.Google Scholar
27.Warnke, RA, Gatter, KC, Brunangelo, F, Hildreth, P, Woolston, RE, Pulford, K, Cordell, JL, Cohen, B, De Wolf-Peeters, C, Mason, DY. Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. New Eng J Med 1983; 309: 1275–1281.CrossRefGoogle ScholarPubMed
28.Mukherji, B, Yagoda, A, Lee, BH, Kradkoff, IH. A clinical study of the natural history of lymphosarcoma and reticulum cell sarcoma. Eur J Cancer 1974; 10: 497–505.CrossRefGoogle ScholarPubMed
29.Henry, J, Heffner, R, Dillard, S, Earle, K. Davis, R. Primary malignant lymphoma of the central nervous system. Cancer 1974; 34: 1293–1302.3.0.CO;2-P>CrossRefGoogle Scholar
30.Littman, P, Wang, CC. Reticulum cell sarcoma of the brain: A review of the literature and a study of 19 cases. Cancer 1975; 35: 1412–1420.3.0.CO;2-T>CrossRefGoogle Scholar
31.Rampen, FH, Van Andel, JG, Sizoo, W, Unnik, J. Radiation therapy in primary non Hodgkin’s lymphoma of the CNS. Eur J Cancer 1980; 16: 177–184.CrossRefGoogle ScholarPubMed
32.Givner, I. Malignant lymphoma with ocular involvement. A clinicopathologic report. Am J Ophthalmol 1955; 39: 29–32.CrossRefGoogle Scholar
33.Parver, LM, Font, RL. Malignant lymphoma of the retina and brain. Initial diagnosis by cytologic examination of vitreous aspirate. Arch Ophthalmol 1979; 97: 1505–1507.CrossRefGoogle ScholarPubMed
34.Rosenbaum, TJ, MacCarty, CS, Buettner, H. Uveitis and cerebral reticulum-cell sarcoma (large-cell lymphoma). Case Report. J Neurosurg 1979; 50: 660–664.CrossRefGoogle ScholarPubMed
35.Stewart, DJ, Russell, N, Atack, EA, Quarrinton, A, Stolback, L. Cyclophosphamide, doxorubicin, vincristine and dexametha-sone in primary lymphoma of the brain: A Case Report. Cancer Treatment Reports 1983; Vol 67 No 3, 287–291.Google ScholarPubMed
36.Amadori, S, Papa, G, Avvisati, G, Petti, Met al. Sequential combination of systemic high dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. J Clin Oncology 1984; 2: 98–101.CrossRefGoogle ScholarPubMed
37.Herbst, KD, Corder, MP, Justice, GR. Successful therapy with methotrexate of a multicentric mixed lymphoma of the central nervous system. Cancer 1976; 38: 1476–1478.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
38.Duttera, MH, Bleyer, WA, Pomeroy, TCet al. Irradiation, methotrexate toxicity and the treatment of meningeal leukemia. Lancet 1973; 2: 703–707.CrossRefGoogle Scholar
39.Wallack, EM, Reavis, WM Jr, Hall, CD. Primary brainstem reticulum cell sarcoma causing dementia. Dis Nerv Syst 1977; 38: 744–747.Google ScholarPubMed
40.Ruff, RL, Petito, CK, Rawlinson, DG. Primary cerebral lymphoma mimicking multiple sclerosis. Arch Neurol 1979; 36: 598.CrossRefGoogle ScholarPubMed
41.Williams, RS, Crowell, RM, Fisher, CMet al. Clinical and radiological remission in reticulum cell sarcoma of the brain. Arch Neurol 1979; 36: 206–210CrossRefGoogle ScholarPubMed
42.Singh, A, Strobos, RJ, Singh, BMet al. Steroid induced remissions in CNS lymphoma. Neurology (NY) 1982; 32: 1267–1271CrossRefGoogle ScholarPubMed
43.Scully, RE, Mark, EJ, McNeely, BU. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 31–1982. New Eng J Med 1982; 307: 359–368.Google Scholar
44.Vaquero, J, Martinez, R, Rossi, E, Lopez, R. Primary cerebral lymphoma: the “ghost tumor”. Case report. J Neurosurg 1984; 60: 174–176.CrossRefGoogle ScholarPubMed
45.Coca, A, Goday, A, Font, J, Ingelmo, M, Balcells, A. Letter to the Editor re: Primary cerebral lymphoma: the “ghost tumor”. J Neurosurg 1984; 61: 202.Google Scholar
46.Kinney, T, Adams, R. Reticulum cell sarcoma of brain. Arch Neurol Psych 1943; 50: 552–564.CrossRefGoogle Scholar
47.Tanaka, T, Nishimoto, A, Doi, A, Nagao, S, Hujita, M, Sesaki, T, Yumoto, T. Primary intracranial malignant lymphomas with particular reference to their pathogenesis. Acta Path Jap 1977; 27(6): 927–940.Google ScholarPubMed
48.Letendre, L, Banks, PM, Freese, DF, Miller, RH, Scanlon, PW, Kiely, JM. Primary lymphoma of the central nervous system. Cancer 1982; 49: 939–943.3.0.CO;2-1>CrossRefGoogle ScholarPubMed