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Postmortem Increases in GABA Receptor Binding To Membranes of Cat Central Nervous System

Published online by Cambridge University Press:  18 September 2015

Godfrey Tunnicliff  and
G.Keith Matheson
Godfrey Tunnicliff
Affiliation:
Evansville Center for Medical Education Indiana University School of Medicine, Evansville, Indiana, U.S.A.
G.Keith Matheson*
Affiliation:
Evansville Center for Medical Education Indiana University School of Medicine, Evansville, Indiana, U.S.A.
*
Associate Professor of Anatomy, Evansville Center for Medical Education, Indiana University School of Medicine, PO Box 3287, Evansville, Indiana 47732 U.S.A
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GABA receptor binding in fifteen regions of cat central nervous system was investigated immediately postmortem and at twelve, twenty-four, and 72 hours postmortem. In each of the supraspinal areas studied, GABA binding increased with time-after-death. Changes after 24 hours occurred in the cerebellum, the visual cortex, the sensorimotor cortex. and the amygdala where more than a twofold increase in binding was observed. Increases were also noted in the thalamus, caudate nucleus, hippocampus, and hypothalamus. The results suggest that caution should be exercised in the interpretation of GABA binding data obtained from human brains that have not been treated in a similar postmortem manner.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 1 , February 1980 , pp. 19 - 21
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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