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The Possible Local Synthesis of Antibodies to Herpes Simplex Virus in Normal Cerebrospinal Fluid

Published online by Cambridge University Press:  18 September 2015

Anthony Science Russell
Anthony Science Russell*
Affiliation:
Rheumatic Disease Unit, University of Alberta, Edmonton, Alberta, Canada
*
Department of Medicine, 9-112 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
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We have used the technique of antibody mediated cell dependent immune lysis to examine paired samples of serum and CSF for antibody to herpes simplex virus. The 40 patients studied had no inflammatory disease of the nervous system, yet 20 of the CSF specimens did have antiviral antibody. This is an extremely sensitive technique for the detection of at least one type of antiviral antibody and “in vitro” is a very effective way of killing virus infected cells. There is no correlation between the level of antiviral antibody in the CSF with the total protein content, but the high CSF: serum antibody ratio in some subjects who are particularly susceptible to recurrent herpes infection raises the possibility that local stimulation and production of this antibody may occur.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 4 , November 1976 , pp. 219 - 221
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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