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Platelet Aggregability in Sleep-Related Stroke

Published online by Cambridge University Press:  18 September 2015

C.L. Voll ,
N. Chetty  and
P. Atkinson
C.L. Voll*
Affiliation:
Department of Neurology, University of the Witwatersrand
N. Chetty
Affiliation:
Department of Pathology, SAIMR, Baragwanath Hospital, Johannesburg
P. Atkinson
Affiliation:
Department of Pathology, SAIMR, Baragwanath Hospital, Johannesburg
*
Department of Patholog, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1
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Abstract:

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We examined platelet aggregability during nocturnal sleep and daytime wakefulness in patients with a history of sleep-related stroke onset (SOS) and compared it to that of matched awake-onset stroke (AOS) patients and controls without evidence of vascular disease. Aggregability was evaluated in-vitro at least seven weeks following stroke onset. Platelets were more aggregable to ADP, collagen and arachidonic acid (AA) during both sleep and wakefulness in patients with AOS (p<0.01). No significant difference in the mean aggregation thresholds during sleeping or waking periods were found between SOS and control groups. However, platelets were significantly more responsive to AA during sleep than during wakefulness in the SOS patients (p<0.01). This difference was confined to the subgroup of SOS patients who had experienced nocturnal as opposed to daytime sleep-related stroke onset, suggesting that the observed difference in platelet responsiveness to AA may be related to a circadian fluctuation in platelet aggregability rather than to a sleep-related fluctuation. Significant sleep-related changes in platelet aggregability were not identified in the other two groups.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 1 , February 1989 , pp. 71 - 77
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

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