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Plasma Lipoprotein Lipase and Hepatic Lipase Activities in Friedreich’s Ataxia

Published online by Cambridge University Press:  18 September 2015

D. Blache ,
D. Bouthillier ,
A. Barbeau  and
J. Davignon
D. Blache
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research and the Department of Neurobiology, Clinical Research Institute of Montreal
D. Bouthillier
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research and the Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research and the Department of Neurobiology, Clinical Research Institute of Montreal
J. Davignon
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research and the Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 West Pine Avenue West, Montréal, Quebec, Canada H2W 1R7
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Plasma triglycerides although within the normal range have been shown to be higher in Friedreich’s ataxia than in control subjects. To determine whether this difference could be ascribed to a reduced catabolism of triglyceride-rich lipoproteins, the activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HL), released into plasma after an heparin injection, were measured in 13 cases of Friedreich’s ataxia and 14 control subjects of comparable signs. LPL was found to be significantly lower in the ataxic patients. Moreover about half of the cases clustered below the normal range for both lipase activities. This subgroup of Friedreich’s patients had significantly higher plasma triglycerides than those with normal lipase activities. Further studies are needed to relate these findings to other characteristics of the disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 191 - 194
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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