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Pituitary Responses to a Neuroactive Tripeptide (TRH) in Friedreich’s Ataxia Families

Published online by Cambridge University Press:  18 September 2015

G. Tolis ,
A. Mehta ,
E. Andermann ,
C. Harvey  and
A. Barbeau
G. Tolis
Affiliation:
Department of Medicine, Division of Endocrinology Royal Victoria Hospital
A. Mehta
Affiliation:
Department of Medicine, Division of Endocrinology Royal Victoria Hospital
E. Andermann
Affiliation:
Department of Neurogenetics, Montreal Neurological Hospital and Institute, McGill University
C. Harvey
Affiliation:
Department of Neurogenetics, Montreal Neurological Hospital and Institute, McGill University
A. Barbeau*
Affiliation:
Institut de recherches cliniques de Montréal, Montréal, Quebec, Canada
*
Prof. André Barbeau, Clinical Research Institute of Montreal, 110 West Pine Avenue West, Montréal, Quebec, Canada H2W 1R7
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Abstract:

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Oral glucose tolerance, thyroid function tests, as well as thyrotropin, prolactin and growth hormone release after administration of thyrotropin releasing hormone, were evaluated in patients with Friedreich’s ataxia and unaffected family members. Impaired glucose tolerance was found in the majority of family members, affected or not. Thyroid hormone levels and PRL and TSH responses to TRH, were similar in all and normal. However, GH responses to TRH were abnormal in half of the patients, but in none of the unaffected family members. Paradoxical responses to neuropeptides may characterize some Friedreich’s ataxia patients, and may predict the possibility of therapeutic maneuvers with such peptides in these patients.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 189 - 190
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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