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Phase II Study of Trimetrexate in Recurrent Anaplastic Glioma: National Cancer Institute of Canada Clinical Trials Group Study

Published online by Cambridge University Press:  18 September 2015

J. Gregory Cairncross ,
Elizabeth A. Eisenhauer ,
David R. Macdonald ,
Michel P. Rathbone ,
Malcolm J. Moore ,
Carol A. Sawka ,
Ronald E. MacCormick  and
Ian G. Kerr
J. Gregory Cairncross
Affiliation:
University of Western Ontario, London
Elizabeth A. Eisenhauer*
Affiliation:
National Cancer Institute of Canada Clinical Trials Group, Queen's University, Kingston
David R. Macdonald
Affiliation:
University of Western Ontario, London
Michel P. Rathbone
Affiliation:
McMaster University, Hamilton
Malcolm J. Moore
Affiliation:
University of Toronto, Toronto
Carol A. Sawka
Affiliation:
University of Toronto, Toronto
Ronald E. MacCormick
Affiliation:
Dalhousie University, Halifax
Ian G. Kerr
Affiliation:
University of Toronto, Toronto
*
National Cancer Institute of Canada, Investigational New Drug Program, Queen's University, 82-84 Barrie St., Kingston, Ontario, Canada K7L 3N6
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Abstract:

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The National Cancer Institute of Canada Clinical Trials Group conducted a phase II trial of trimetrexate given in a daily × 5 intravenous bolus schedule every 3 weeks in patients with measurable recurrent anaplastic glioma and limited prior treatment. There were no responses in 14 evaluable patients. We conclude that trimetrexate, given as described, is not an active agent in this disease.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 21 - 23
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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