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Pharmacological Modification of Bradykinin Induced Breakdown of the Blood-brain Barrier

Published online by Cambridge University Press:  18 September 2015

Jennifer J. Raymond ,
David M. Robertson  and
Henry B. Dinsdale
Jennifer J. Raymond
Affiliation:
Departments of Pathology and Medicine, Queen's University and Kingston General Hospital, Kingston
David M. Robertson*
Affiliation:
Departments of Pathology and Medicine, Queen's University and Kingston General Hospital, Kingston
Henry B. Dinsdale
Affiliation:
Departments of Pathology and Medicine, Queen's University and Kingston General Hospital, Kingston
*
Department of Pathology, Queen's University, Kingston, Ontario, Canada K7L 3N6
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Abstract:

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Internal carotid artery infusion of bradykinin caused extensive breakdown of the blood-brain barrier to protein as demonstrated by the extravasation of the marker, horseradish peroxidase, into vessel walls and the adjacent parenchyma. Pretreatment of the animals with indomethacin, trifluoperazine, or imidazole significantly reduced the quantity of abnormally permeable vessels as determined by light microscopy. By electron microscopy, it was determined that bradykinin caused an intense increase in the number of pinocytotic vesicles in the permeable segments, but no change in the interendothelial junctions. After imidazole pretreatment, although the extent of the permeability change was markedly reduced, the intensity of pinocytotic activity in the involved areas was not altered.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 3 , August 1986 , pp. 214 - 220
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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