Hostname: page-component-848d4c4894-mwx4w Total loading time: 0 Render date: 2024-06-28T15:38:21.844Z Has data issue: false hasContentIssue false
  • English
  • Français

Pharmacological Modification of Blood-Brain Barrier Permeability Following a Cold Lesion

Published online by Cambridge University Press:  18 September 2015

Jennifer J. Raymond ,
David M. Robertson ,
Henry B. Dinsdale  and
Sukriti Nag
Jennifer J. Raymond*
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
David M. Robertson
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
Henry B. Dinsdale
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
Sukriti Nag
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
*
Queen’s University, Department of Pathology, Richardson Laboratory, Kingston, Ontario, Canada K7L 3N6
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effect of desipramine, imidazole, thioridazine and trifluoperazine on blood-brain barrier(BBB) permeability after a 24 hour cold lesion was studied in rats. Changes in BBB permeability were determined using a quantitative horseradish peroxidase (HRP) assay. The four drugs tested did not alter the quantity of HRP in the cortex of control animals, or in the contralateral cortex of test animals. However, imidazole, desipramine and trifluoperazine significantly reduced the HRP extravasation in and around the cold lesion. Several mechanisms for this effect are suggested; one possible mechanism common to all these drugs is the reduction of increased vesicular transport in cortical vessels adjacent to the cold lesions.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 447 - 451
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Baker, RN., Cancilla, PA., Pollock, PS. and Frommes, SP. (1971) The movement of exogenous protein in experimental cerebral edema. An electron microscopic study of freeze injury. J. Neuropathol. Exp. Neurol., 30: 668–679.CrossRefGoogle ScholarPubMed
Bengtsson, E. (1977) Studies on the mechanism of the breakdown of the blood-aqueous barrier in the rabbit eye. Acta Ophthalmol. Suppl., 130: 1–33.Google ScholarPubMed
Cancilla, PA., Frommes, SP., Kahn, LE. and DeBault, LE. (1979) Regeneration of cerebral microvessels. A morphologic and histochemical study after local freeze-injury. Lab. Invest., 40: 74–82.Google ScholarPubMed
Connor, CG., Brady, RC. and Brownstein, BL. (1981) Trifluoperazine inhibits spreading and migration of cells in culture. J. Cell Physiol., 108: 299–307.CrossRefGoogle ScholarPubMed
Cotran, RS. and Karnovsky, MJ. (1967) Vascular leakage induced by horse-radish peroxidase in the rat. Proc. Soc. Exp. Biol. Med., 126: 557–561.CrossRefGoogle Scholar
Diemann, W., Taugner, R. and Fahimi, HD. (1976) Arterial hypotension induced by horseradish peroxidase in various rat strains. J. Histochem. Cytochem., 24: 1213–1217.CrossRefGoogle Scholar
Faubel, F., Reulen, HJ., Muller, D., and Schurmann, K. (1976) Double-blind study on the effects of steroids on severe closed head injury. Dynamics of brain oedema, edited by Pappius, H.M., Feindel, W., Springer Verlag, Berlin337–343.CrossRefGoogle Scholar
Fauster, R., Honnegger, U. and Weismann, U. (1983) Inhibition of phospholipid degradation and changes of the phospholipid-pattern by desipramine in cultured human fibroblasts. Biochem. Pharmacol., 32: 1737–1744.CrossRefGoogle ScholarPubMed
Flower, RJ. and Blackwell, GJ. (1976) The importance of phospholipidase-A2 in prostaglandin biosynthesis. Biochem. Pharmacol., 25: 285–291.CrossRefGoogle ScholarPubMed
Goodman, HM. (1969) Metabolic effects of imidazole in adipose tissue. Biochim. Biophys. Acta, 176: 60–64.CrossRefGoogle ScholarPubMed
Goto, Y. and Watanabe, K. (1978) Anti-secretory effect of imidazole and its derivatives in an isolated gastric mucosa preparation and an anesthetized young chicken preparation: comparison with a histamine H2-receptor antagonist. Jpn. J. Pharmacol., 28: 185–195.CrossRefGoogle Scholar
Gross, PM. (1982) Cerebral Histamine: Indications for neuronal and vascular regulation. J. Cereb. Blood Flow Metab., 2: 3–23.CrossRefGoogle ScholarPubMed
Gross, PM., Teasdale, GM., Graham, DI., Angerson, WJ. and Harper, MA. (1982) Intra-arterial histamine increases blood-brain transport in rats. Am. J. Physiol., 243: H307–H317.Google ScholarPubMed
Hansson, HA., Johansson, BB. and Blomstrand, C. (1975) Ultrastructural studies on cerebrovascular permeability in acute hypertension. Acta Neuropathol. (Berl.), 32: 187–198.CrossRefGoogle ScholarPubMed
Hansson, HA. and Johansson, BB. (1980) Induction of pinocytosis in cerebral vessels by acute hypertension and by hyperosmolar solutions. J. Neurosci. Res., 5: 183–190.CrossRefGoogle ScholarPubMed
Hoppe, E., Christensen, L. and Christensen, KN. (1981) The clinical outcome of patients with severe head injuries, treated with high-dose dexamethasone, hyperventilation and barbiturates. Neurochirurgia, 24: 17–20.Google Scholar
Horwitz, SB., Chia, GH., Harracksingh, C., Orlow, S., Pifko-Hirst, S., Schneck, J., Sorbara, L., Speaker, M., Wilk, EW. and Rosen, OM. (1981) Trifluoperazine inhibits phagocytosis in a macrophage-like cultured cell line. J. Cell Biol., 91: 798–802.CrossRefGoogle Scholar
Johansson, BB. (1981) Pharmacological modification of hypertensive blood-brain barrier opening. Acta Pharmacol. Toxicol., 48: 242–247.CrossRefGoogle Scholar
Joo, FZ., Rakonczay, Z. and Wolleman, M. (1975) cAMP-mediated regulation of the permeability in the brain capillaries. Experientia (Basel), 31: 582–584.CrossRefGoogle ScholarPubMed
Josefsson, JO., Johansson, G. and Hansson, SE. (1975) Inhibition of induced pinocytosis in Amoeba proteus by membrane stabilizing drugs. Acta Physiol. Scand., 95: 270–285.CrossRefGoogle ScholarPubMed
Kanof, PD. and Greengard, P. (1978) Brain histamine receptors as targets for antidepressant drugs. Nature, 272 (5651): 329–333.CrossRefGoogle ScholarPubMed
Kontos, HA., Wei, EP., Povlishock, JT., Dietrich, WD., Magiera, CJ. and Ellis, EF. (1980) Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science, 209: 1242–1245.CrossRefGoogle ScholarPubMed
Lowry, OH., Rosebrough, NJ., Farr, AL. and Randall, RJ. (1951) Protein measurement with the folin reagent. J. Biol. Chem., 193: 265–275.CrossRefGoogle Scholar
Mitchell, J., Weller, RO. and Evans, H. (1979) Re-establishment of the blood-brain barrier to peroxidase following cold injury to mouse cortex. Acta Neuropathol. (Berl.), 46: 45–49.CrossRefGoogle Scholar
Morris, HC. and Dragstedt, CA. (1945) The antihistaminic effect of imidazol. Proc. Soc. Exp. Biol. Med., 59: 311.CrossRefGoogle Scholar
Moskowitz, N., Shapiro, L., Schook, W. and Puszkin, S. (1983) Phospholipase A2 modulation by calmodulin, prostaglandins and cyclic nucleotides. Biochem. Biophys. Res. Comm., 115: 94–99.CrossRefGoogle ScholarPubMed
Nag, S., Robertson, DM. and Dinsdale, HB. (1977) Cerebral cortical changes in acute hypertension. An Ultrastructural Study. Lab. Invest., 36: 150–161.Google ScholarPubMed
Palacios, JM., Garbarg, M., Barbin, G. and Schwartz, JC. (1978) Pharmacological characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in slices from guinea-pig hippocampus. Mol. Pharmacol., 14: 971–982.Google ScholarPubMed
Pappius, HM. (1981) Local cerebral glucose utilization in thermally traumatized rat brain. Ann. Neurol., 9: 484–491.CrossRefGoogle ScholarPubMed
Pappius, HM. and Wolfe, LS. (1983) Functional disturbances in brain following injury: Search for underlying mechanisms. Neurochem. Res., 8: 63–72.CrossRefGoogle ScholarPubMed
Portaleone, P., Pagnini, G., Crispino, A. and Genazzani, E. (1978). Histaminesensitive adenylate cyclase in hypothalamus of rat brain: H1 and H2 receptors. J. Neurochem., 31: 1371–1374.CrossRefGoogle ScholarPubMed
Poste, G. and Reeve, P. (1972) Inhibition of virus-induced cell fusion by local anaesthetics and phenothiazine tranquillizers. J. Gen. Virol., 16: 21–28.CrossRefGoogle Scholar
Preskhorn, SM., Hartman, BK., Raichle, ME. and Clark, HB. (1980) The effect of dibenzazepines (tricyclic antidepressants) on cerebral capillary permeability in the rat in vivo. J. Pharmacol. Exp. Ther., 213: 313–320.Google Scholar
Puig-Parellada, P., Garcia-Gasulla, G. and Puig-Muset, P. (1973) Pharmacological properties of imidazole. I. Analgesic and anti-inflammatory actions. Pharmacol., 10: 161–168.CrossRefGoogle ScholarPubMed
Seaman, KB. and Daly, JW. (1982) Calmodulin stimulation of adenylate cyclase in rat brain membranes does not require GTP. Life Sci., 30: 1457–1464.CrossRefGoogle Scholar
Sobue, K., Ichida, S., Yoshida, H., Yamazaki, R. and Kakiuchi, S. (1979) Occurrence of a Ca2+ and modulator protein-activatable ATPase in the synaptic plasma membranes of brain. F.E.B.S. Lett., 99: 199–202.CrossRefGoogle ScholarPubMed
Steinman, RM. and Cohn, ZA. (1972) The interaction of soluble horseradish peroxidase with mouse peritoneal macrophages in vitro. J. Cell Biol., 55: 186–204.CrossRefGoogle ScholarPubMed
Svensson, TH. and Usdin, T. (1978) Feedback inhibition of brain noradrenaline neurons by tricyclic anti-depressants: a-receptor mediation. Science, 202: 1089–1091.CrossRefGoogle Scholar
Vetulani, J. and Sulser, F. (1975) Action of various anti-depressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature, 257 (5526): 495–496.CrossRefGoogle Scholar
Westergaard, E. (1975) The effect of serotonin, norepinephrine and cyclic AMPon the blood-brain barrier. J. Ultrastruct. Res., 50: 383.Google Scholar
Westergaard, E., Hertz, MM. and Bol wig, TG. (1978) Increased horseradish peroxidase across cerebral vessels, evoked by electrically induced seizures in the rat. Acta Neuropathol. (Berl.), 41: 73–80.CrossRefGoogle ScholarPubMed
Zink, HA., Podos, SM. and Becker, B. (1973) Inhibition by imidazole of the increase in intraocular pressure induced by topical prostaglandin E. Nature (New Biol.), 245: 21–22.CrossRefGoogle ScholarPubMed
Zink, HA., Podos, SM. and Becker, B. (1975) Modification by imidazoles of ocular inflammatory and pressure responses. Invest. Ophthalmol., 14: 280–285.Google Scholar