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Peripheral Neurophathies Associated With Chronic Renal Failure

Published online by Cambridge University Press:  18 September 2015

C.F. Bolton
C.F. Bolton*
Affiliation:
Department of Clinical Neurological Sciences, Victoria Hospital, University of Western Ontario, London, and the Department of Medicine, University Hospital, University of Saskatchewan, Saskatoon, Canada
*
Department of Clinical Neurological Sciences, Victoria Hospital, South Street Campus, London, Ontario, Canada, N6A 4G5, Canada
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A variety of peripheral nerve disorders may be associated with chronic renal failure. The polyneuropathy due to uremic toxins is a distal, motor and sensory polyneuropathy in which there is segmental demyelination, axonal degeneration, and segmental remyelination. The nature of the uremic toxin and the underlying mechanism of these changes is unknown.

The incidence in patients with “endstage” renal disease has fallen in recent years, severe cases now being rare, perhaps due to refinements in chronic hemodialysis, transplantation, and other therapies. However, while chronic hemodialysis stabilizes uremic neuropathy, manipulation of hemodialysis schedules may not alter its course, according to current assessment. Successful renal transplantation improves both the clinical and electrophysiological signs, even in severe uremic neuropathy.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 2 , May 1980 , pp. 89 - 96
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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