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Peripheral Neuropathy in Oxalosis. A Case Report with Electron Microscopic Observations

Published online by Cambridge University Press:  18 September 2015

Juan M. Bilbao ,
Henry Berry ,
Joseph Marotta  and
Roderick C. Ross
Juan M. Bilbao*
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Henry Berry
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Joseph Marotta
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
Roderick C. Ross
Affiliation:
Departments of Pathology and Neurology, St. Michaels Hospital, and the University of Toronto
*
Department of Pathology, St. Michaels Hospital, 30 Bond Street, Toronto M5B IW8, Ontario, Canada
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A 61 year old man had chronic renal failure because of oxaluria and renal calculi. Two years before death, while on hemodialysis, he developed severe progressive peripheral neuropathy. At autopsy calcium oxalate crystals were found in the peripheral nerves and other tissues. Nerve lesions included segmental demyelination, axonal degeneration and crystalline deposits within the myelin sheath. Ultrastructurally there were foci of osmiophilic granular material within myelin lamellae and endoneurium, and pleomorphic lamellar bodies in the perinuclear Schwann cell cytoplasm.

It is probable that chronic hemodialysis favors the deposition of oxalate in the Schwann cells and the development of neuropathy in patients with primary hyperoxaluria and renal failure.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 1 , February 1976 , pp. 63 - 67
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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