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Parkinson's Disease and Exposure to Rural Environmental Factors: A Population Based Case-Control Study

Published online by Cambridge University Press:  18 September 2015

Karen M. Semchuk ,
Edgar J. Love  and
Robert G. Lee
Karen M. Semchuk*
Affiliation:
Departments of Community Health Sciences, Faculty of Medicine, The University of Calgary, Calgary
Edgar J. Love
Affiliation:
Departments of Community Health Sciences, Faculty of Medicine, The University of Calgary, Calgary
Robert G. Lee
Affiliation:
Departments of Clinical Neurosciences, Faculty of Medicine, The University of Calgary, Calgary
*
Centre for Agricultural Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X0
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Abstract:

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To determine whether a history of exposure to rural environmental factors leads to an increased likelihood of developing idiopathic Parkinson's disease, we conducted a case-control study of 130 cases and 260 randomly selected community controls (matched with the cases by sex and age ± 2.5 years at a ratio of 2 controls: 1 case) in the city of Calgary. The data were collected by personal interviews and were analyzed using conditional logistic regression for matched sets. The ages of the cases ranged from 36.5 to 90.7 years (mean = 68.5 ± 11.3 years). The mean age at diagnosis was 61.1 ± 12.4 years. The mean duration of disease was 7.8 ± 0.6 years. Eleven (9.1%) cases were diagnosed before age 40. In this sample from the Province of Alberta, Canada, no significant increase in risk for Parkinson's disease was associated with a history of rural living, farm living, or well water drinking in early childhood or at any time during the first 45 years of life.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 3 , August 1991 , pp. 279 - 286
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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