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Parkinson's Disease: A Genetic Study

Published online by Cambridge University Press:  18 September 2015

Ma. Elisa Alonso ,
Enrique Otero ,
Rosalinda D'Regules  and
Hector Hugo Figueroa
Ma. Elisa Alonso*
Affiliation:
Genetics Department, National Institute of Neurology and Neurosurgery, Mexico City
Enrique Otero
Affiliation:
Neurology Division, National Institute of Neurology and Neurosurgery, Mexico City
Rosalinda D'Regules
Affiliation:
Psychology Department, National Institute of Neurology and Neurosurgery, Mexico City
Hector Hugo Figueroa
Affiliation:
Genetics Department, National Institute of Neurology and Neurosurgery, Mexico City
*
Genetic Department Instituto Nacional de Neurologia Y Neurocirugia, Insurgentes Sur 3877, Col. La Fama — Deleg, Tlalpan 14410 Mexico, D.F.
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Abstract:

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A sample of 122 patients with Parkinson's Disease was studied for the purpose of investigating if the frequency of relatives affected with Parkinson in this group was higher than in a control group and to see if the genetic load was more important in some of the subtypes of Parkinson described by Barbeau and Pourcher (1982).7 In our 122 patients, we found that 1.7% were post-encephalic parkinsonian, 12.3% were symptomatic cases and 86% of the idiopathic variety. There were 16.1% early onset patients in the idiopathic group and among these we found 23.5% with a positive family history of Parkinson in the first-degree relatives. In 6 cases with the tremor onset form of the disease, the family history was positive and 5 patients, 4.7% had familial essential tremor-related Parkinsonism. Our results support Barbeau's hypothesis7.19 that Parkinson is a heterogeneous disease in which some subtypes (such as early onset Parkinson) have an important genetic subceptibility component.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 3 , August 1986 , pp. 248 - 251
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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