Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-16T15:15:29.076Z Has data issue: false hasContentIssue false
  • English
  • Français

P300 in Behcet's Patients without Neurological Manifestations

Published online by Cambridge University Press:  02 March 2017

Hulusi Kececi  and
Melih Akyol
Hulusi Kececi*
Affiliation:
Department of Neurology, Medical Faculty of Cumhuriyet University, Sivas, Turkey
Melih Akyol
Affiliation:
Department of Dermatology, Medical Faculty of Cumhuriyet University, Sivas, Turkey
*
Mehmet Pasa M. Hersek S. Guldas Apt. No:1/6 58040-Sivas, Turkey.
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

Behcet's disease is the association of recurrent aphthous stomatitis with genital ulceration and eye disease. Neurologic involvement patterns include meningomyelitis, a brain stem syndrome, pyramidal and extrapyramidal abnormality and stroke. In the present study, subclinical involvement was investigated by using P300 in Behcet's patients without neurological manifestation.

Methods:

Fifteen patients and 15 healthy volunteers were accepted for the study. P300 from vertex (Cz) electrode sites of the 10-20 system using electrodes and motor response time were recorded.

Results:

Patients had significantly prolonged latencies of P300 as compared to normal controls (p=0.013) but no significant differences in amplitude (p=1.000). Patients showed a significantly delayed motor response time than controls (p=0.006). Nine patients (60 %) had P300 latency and eight patients (53.3 %) had motor response time values exceeding the mean of controls by two standard deviations.

Conclusion:

The findings suggest that the P300 measures and motor response time may reflect subclinical neurologic involvement in Behcet's disease.

Résumé:

RÉSUMÉ:Objectif:

La maladie de Behcet comprend une stomatite aphteuse accompagnée d'ulcérations génitales et d'une maladie oculaire. L'atteinte neurologique inclut la méningomyélite, un syndrome du tronc cérébral, des anomalies pyramidales et extrapyramidales et l'accident vasculaire cérébral. Dans cette étude, l'atteinte subclinique a été investiguée au moyen de potentiels évoqués P300 chez des patients atteints de la maladie de Behcet sans manifestations neurologiques.

Méthodes:

Quinze patients et 15 volontaires sains ont été recrutés pour cette étude. les potentiels évoqués P300 de sites d'électrodes au vertex du système 10-20 utilisant des électrodes et le temps de la réponse motrice ont été enregistrés.

Résultats:

Les patients avaient des temps de latence P300 significativement prolongés comparés aux contrôles sains (p=0.013), sans différence significative de l'amplitude (p=1.000). Les patients avaient un temps de réponse motrice significativement retardé par rapport aux contrôles (p=0.006). Neuf patients (60%) avaient une latence P300 et huit patients (53.3%) avaient un temps de réponse motrice supérieur à deux déviations standards au-dessus de la moyenne des contrôles.

Conclusion:

Ces observations suggèrent que les mesures de potentiels évoqués P300 et le temps de réponse motrice pourraient refléter une atteinte neurologique subclinique dans la maladie de Behcet.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 28 , Issue 1 , February 2001 , pp. 66 - 69
Copyright
Copyright © The Canadian Journal of Neurological 2001

References

REFERENCES

1. Nadeau, SE, Watson, RT. Neurologic manifestations of vasculitis and collagen vascular syndromes. In: Joynt, RJ, editor. Clinical Neurology. Philadelphia: JB Lippincott Company, 1992:1–166.Google Scholar
2. Chajec, T, Fainaro, M. Behcet’s disease: report of 41 cases and a review of the literature. Medicine 1975; 54:179–195.Google Scholar
3. O’Duffy, JD, Goldstein, NP. Neurologic involvement in 7 patients with Behcet’s disease. Am J Med 1976; 61:170–178.Google Scholar
4. Chamberlain, MA. Behcet’s syndrome in 32 patients in Yorkshire. Ann Rheum Dis 1977; 36: 491–498.Google Scholar
5. Oken, BS. Endogenous event-related potentials. In: Chiappa, KH, ed. Evoked Potentials in Clinical Medicine. Philadelphia: JB Lippincott Company, 1997: 529–563.Google Scholar
6. Duffy, FH, Denckla, MB, Bartels, PH, et al. Dyslexia: automated diagnosis by computerized classification of brain electrical activity. Ann Neurol 1980; 7: 421–428.CrossRefGoogle ScholarPubMed
7. John, ER, Prichep, LS, Friedman, J, et al. Neurometrics: computer-assisted differential diagnosis of brain dysfunctions. Science 1988; 239:162–169.Google Scholar
8. Goodin, DS, Aminoff, MJ. Electrophysiological differences between demented and nondemented patients with Parkinson’s disease. Ann Neurol 1987; 21:90–94.Google Scholar
9. Gordon, E, Kraiuhin, C, Harris, A, et al. The differential diagnosis of dementia using P300 latency. Biol Psychiatry 1986; 21:1123–1132.Google Scholar
10. Ito, J. Somatosensory event-related potentials (ERPs) in patients with different types of dementia. J Neurol Sci 1994; 12:139–146.Google Scholar
11. Cohen, SN, Syndulko, K, Rever, B, et al. Visual evoked potentials and long latency event-related potentials in chronic renal failure. Neurology 1983; 33:1219–1222.Google Scholar
12. Rosenberg, C, Nudleman, K, Starr, A. Cognitive evoked potentials (P300) in early Huntington’s disease. Arch Neurol 1985; 42:984–987.Google Scholar
13. Polich, J, Romine, JS, Sipe, JC, et al. P300 in multiple sclerosis: a preliminary report. Ind J Psychophysiol 1992; 12:155–163.Google Scholar
14. Goodin, DS, Aminoff, MJ, Chequer, RS. Effect of different high-pass filters on the long latency event-related auditory evoked potentials in normal human subject and individuals infected with the human immunodeficiency virus. J Clin Neurophysiol 1992; 9:97–104.Google Scholar
15. Pfefferbaum, A, Wenegrad, BG, Ford, JM, et al. Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 1984;59:104–124.Google Scholar
16. Strigsby, B, Bohlega, S, al-Kawi, MZ, et al. Evoked potential findings in Behcet’s disease. Brain stem auditory, visual and somatosensory evoked potentials in 44 patients. Electroencephalogr Clin Neurophysiol 1994; 92:273–281.Google Scholar
17. Parisi, L, Terracciano, ME, Valente, GO, et al. Presymptomatic neurogical involvement in Behcet’s disease: the diagnostic role of magnetic transcranial stimulation. Electroencephalogr Clin Neurophysiol 1996; 101: 42–47.Google Scholar
18. Kao, CH, Lan, JL, Changlai, SP, et al. Technetium-99m-HMPAO SPECT and MRI of brain in patients with neuro-Behcet’s syndrome. Jpn J Psychiatry Neurol 1994 ;48: 77–84.Google Scholar
19. Arai, T, Mizukami, K, Sasaki, M, et al. Clinicopatholgical study in a case of neuro-Behcet’s disease: with special reference to MRI, SPECT and neuropathological findings. Jpn J Psychiatry Neurol 1994; 48: 77–84.Google Scholar
20. Trotta, F, Bajocchi, G, Colamussi, P, et al. Cerebral hypoperfusion detected by SPECT in early neuro-Behcet’s syndrome. Nucl Med Commun 1998; 19: 777–780.Google Scholar
21. Garcia-Burillo, A, Castell, J, Fraile, M, et al. Technetium-99 m-HMPAO brain SPECT in Behcet’s disease. J Nucl Med 1988; 39: 950–954.Google Scholar
22. Avci, O, Kutluay, E, Argon, M, et al. Subclinical cerebral involvement in Behcet’s disease: a SPECT study. Eur J Neurol 1998; 5: 49–53.Google Scholar
23. Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s Disease. Lancet 1990; 5: 1078–1080.Google Scholar
24. O’Duffy, JD. Behcet’s syndrome. New Eng J Med, 1990; 322: 326–328.Google Scholar
25. Serdaroglu, P, Yazici, H, Ozdemir, C, et al. Neurologic involvement in Behcet’s syndrome. Arch Neurol 1989; 46: 265–269.Google Scholar