Background: Mononeuritis multiplex is a painful, asymmetrical peripheral neuropathy involving motor and sensory nerves. This neurological condition is classically associated with systemic diseases such as connective tissue disorders, vasculitis, hematologic diseases including cryoglobulinaemia and amyloidosis. It has also been reported infrequently as a paraneoplastic or post infectious disorder. Methods: Case report Results: We are reporting a case of a 35-year-old man who presented with mononeuritis multiplex following an infectious mononucleosis associated with a mixed cryoglobulinemia. He was treated with IVIG, IV pulse steroid and a prednisone taper over 7 months. Later on, he had a nerve transfer from FCR (flexor carpi radialis) to ECRB (extensor carpi radialis brevis) and PIN (posterior interosseous nerve) due to complete denervation of the PIN without evidence of spontaneous recovery. Conclusions: Acute EBV infection should be suspected in the setting of mononeuritis multiplex. This is the first reported case of nerve transfer for this type of nerve injury.