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Oral Lecithin and Linoleic Acid in Friedreich’s Ataxia: III. Biochemical Results

Published online by Cambridge University Press:  18 September 2015

S.B. Melancon ,
L. Dallaire ,
M. Potier ,
J. Cousineau ,
M. Vanasse ,
G. Geoffroy ,
G. Fontaine  and
B. Grignon
S.B. Melancon
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
L. Dallaire
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
M. Potier
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
J. Cousineau
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
M. Vanasse
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
G. Geoffroy
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
G. Fontaine
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
B. Grignon
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
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Lecithin and sqfflower oil brought about the same changes in serum LAD activity and kinetics in patients with Friedreich’s Ataxia as in controls when results of this double-blind crossover study were analyzed according to group assignation. According to functional stages, pretrial LAD activity decreased with advancing severity while Km for lipoamide increased. Lecithin and sqfflower oil supplements corrected the elevated Km for lipoamide but produced a further reduction in LAD activity. These changes may have been due to the increased intake of linoleic acid, a precursor of lipoic acid, which is present in high percentage in both lecithin and safflower oil. Results of the biochemical study thus agreed with the clinical data gathered during the course of the one-year trial in suggesting that linoleic acid may well have been the active factor through which biochemical and clinical improvement was previously observed in patients with Friedreich’s Ataxia supplemented with lecithin.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 165 - 169
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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