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Oral Lecithin and Linoleic Acid in Friedreich’s Ataxia: I. Design of the Study, Material and Methods

Published online by Cambridge University Press:  18 September 2015

S.B. Melancon ,
L. Dallaire ,
M. Potier ,
M. Vanasse ,
P. Marois ,
G. Geoffroy  and
A. Barbeau
S.B. Melancon
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
L. Dallaire
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
M. Potier
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
M. Vanasse
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
P. Marois
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
G. Geoffroy
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
A. Barbeau*
Affiliation:
Le centre de recherche pédiatrique, Hôpital Sainte-Justine, Université de Montréal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montréal, Quebec, Canada H2W 1R7
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A clinical and biochemical evaluation of twenty-two patients with Friedreich’s Ataxia and ten normal controls was undertaken in 1980 to assess the effect of lecithin and linoleic acid supplements on the course of the disease. The trial consisted of two consecutive six months periods on either supplements in a double-blind crossover fashion. Clinical appraisal was performed with regards to the following parameters: joints mobility, muscle strength, equilibrium, coordination, motor accuracy, speech and numerous day to day activities. Blood samples were obtained at the beginning and in the course of the trial for enzymatic determinations. This paper describes the methodology of the study.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 151 - 154
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

REFERENCES

Barbeau, A., Butterworth, R.F., Ngo, T., Breton, G., Melançon, S., Shapcott, D., Geoffroy, G., and Lemieux, B. (1976) Pyruvate metabolism in Friedreich’s ataxia, Canad. J. neurol. Sci., 3: 379–388.Google Scholar
Barbeau, A. (1978a) Emerging treatments – Replacement therapy with choline or lecithin in neurological diseases, Cand. J. Neurol. Sci., 5: 157–160.Google ScholarPubMed
Barbeau, A. (1978b) Lecithin in neurologic disorders. N. Engl. J. Med., 299: 200–201.Google ScholarPubMed
Barbeau, A. (1979) Lecithin in movement disorders. In: Barbeau, A., Growdon, J.H., Wurtman, R.J., eds. Nutrition and the brain. Vol. 5, New York: Raven Press, 263–271.Google Scholar
Blass, J.P., Kark, R.A.P., Menon, N.K., and Harris, S.E. (1976) Low activities of pyruvate and oxoglutarate dehydrogenase complex in five patients with Friedreich’s ataxia. N. Engl. J. Med., 295: 62–67.CrossRefGoogle ScholarPubMed
Chamberlain, S., Robinson, N., Walker, J., Smith, C., Benton, S., Kennard, C., Swash, M., Kilkenny, B. and Brandbury, S. (1980) Effect of lecithin on Disability and plasma free-choline levels in Friedreich’s Ataxia. J. Neurol. Neurosurg. Psychiatry, 43: 843–845.CrossRefGoogle ScholarPubMed
Filla, A., Butterworth, R.F., Geoffroy, G., Lemieux, B. and Barbeau, A. (1978) Serum and platelet lipoamide dehydrogenase in Friedreich’s ataxia. Can. J. Neurol. Sci. 5: 111–114.CrossRefGoogle ScholarPubMed
Geoffroy, G., Barbeau, A., Breton, G., Lemieux, B., Aube, M., Leger, C. and Bouchard, J.P. (1976) Clinical description and roentgenologic evaluation of patients with Friedreich’s ataxia. Canad. J. Neurol. Sci., 3: 279–286.CrossRefGoogle ScholarPubMed
Kendall, H.D., Kendal, F.P. and Wadsworth, G.E. (1974). Les muscles. Bilan et étude fonctionnelle. Ed. S, Maloine, A., Paris, France.Google Scholar
Legg, N.J. (1978) Oral choline in cerebellar ataxia, Brit. Med. J., ii: 1403.Google Scholar
Legg, N.J. (1979) Oral choline in cerebellar ataxia, Brit. Med. J., ii: 133.CrossRefGoogle Scholar
Livingstone, I.R., Mastaglia, F.L., Pennington, R.J.T. and Skilbeck, C. (1981) Choline chloride in the treatment of cerebellar and spino-cerebellar ataxia. J. Neurol. Sci. 50: 161–174.CrossRefGoogle Scholar
Melançon, S.B., Dallaire, L. and Potier, M. (1978) Lipoamide dehydrogenase in cultured human skin fibroblasts. Clin. Chim. Acta. 87: 29–34.CrossRefGoogle ScholarPubMed
Melançon, S.B., Fontaine, G., Geoffroy, G., Vanasse, M., Dallaire, L. and Potier, M. (1980) Correlation between serum lipoamide dehydrogenase activity and phosphatidylcholine therapy in Friedreich’s ataxia. Can. J. Neurol. Sci. 7: 413–416.CrossRefGoogle ScholarPubMed
Pentland, B., Martyn, C.N., Steer, C.R. and Christie, J.E. (1981) Lecithin in Friedreich’s ataxia. Br. Med. J. 282: 1197–1198.CrossRefGoogle ScholarPubMed
Philcox, D.V. and Kies, B. (1979) Choline in hereditary ataxia. Brit. Med. J., ii: 613.CrossRefGoogle Scholar
Pourcher, E. and Barbeau, A. (1980) Field testing of an ataxia scoring and staging system. Can. J. Neurol. Sci. 7: 339–344.CrossRefGoogle ScholarPubMed
Richards, C, Bouchard, J.P., Bouchard, R. and Barbeau, A. (1980) A preliminary study of dynamic muscle function in hereditary ataxias. Can. J. Neurol. Sci. 7:367–378.CrossRefGoogle Scholar