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New Approaches to the Treatment of Age-Related Brain Disorders

Published online by Cambridge University Press:  18 September 2015

M. Da Prada
M. Da Prada*
Affiliation:
Pharma Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland
*
Pharma Research Department, F. Hoffmann-La Roche Ltd., Ch-4002 Basel, Switzerland
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Abstract:

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Two novel reversible enzyme inhibitors involved in monoamine metabolism are described. The novel and reversible inhibitors are the catechol-O-methyl-transferase (COMT) inhibitor, Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), and the monoamine oxidase type-B (MAO-B) inhibitor, Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide HC1). These may be of special therapeutic benefit in Parkinson's and Alzheimer's diseases.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 384 - 386
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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