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Neuropsychological Deficits and Sleep in Myotonic Dystrophy

Published online by Cambridge University Press:  18 September 2015

R. Broughton ,
D. Stuss ,
M. Kates ,
J. Roberts  and
W. Dunham
R. Broughton*
Affiliation:
Division of Neurology, Ottawa General Hospital and University of Ottawa, Ottawa, Ontario
D. Stuss
Affiliation:
Division of Neurology, Ottawa General Hospital and University of Ottawa, Ottawa, Ontario
M. Kates
Affiliation:
Division of Neurology, Ottawa General Hospital and University of Ottawa, Ottawa, Ontario
J. Roberts
Affiliation:
Division of Neurology, Ottawa General Hospital and University of Ottawa, Ottawa, Ontario
W. Dunham
Affiliation:
Division of Neurology, Ottawa General Hospital and University of Ottawa, Ottawa, Ontario
*
Division of Neurology, Ottawa General Hospital, 501 Smyth Road, Ottawa, Canada K1H 8L6
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Abstract:

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Eight patients with myotonic dystrophy underwent comprehensive neuropsychological testing and overnight polysomnography to assess whether the waking cognitive impairment might be attributable to sleep structure abnormalities or to sleep-related respiratory problems. Patients showed substantial neuropsychological deficits, fragmented nocturnal sleep and, in half the patients, sleep apnea and/or hypopnea both mainly of central type. There was no statistically significant correlation between the degree of daytime cognitive deficit and the degree of sleep fragmentation or of respiratory problems at night. It was concluded that the neuropsychological deficit in mytonic dystrophy cannot be attributed to a secondary effect of nocturnal sleep apnea or sleep disruption but probably represents a direct effect of CNS lesions.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 410 - 415
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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