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Neuropsychological and Glucose Metabolic Profiles in Asymmetric Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

Erich Mohr ,
Ulrike M. Mann ,
Robert S. Miletich ,
Margaret Sampson ,
Terry E. Goldberg ,
J. David Crimes  and
Thomas N. Chase
Erich Mohr*
Affiliation:
Institute of Mental Health Research, University of Ottawa, Ottawa
Ulrike M. Mann
Affiliation:
University of Hamburg, University Hospital Eppendorf, Department of Neurology, Hamburg, Federal Republic of Germany
Robert S. Miletich
Affiliation:
National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland
Margaret Sampson
Affiliation:
Institute of Mental Health Research, University of Ottawa, Ottawa
Terry E. Goldberg
Affiliation:
National Institutes of Health, National Institute of Mental Health, St. Elisabeth Hospital, Washington, D.C.
J. David Crimes
Affiliation:
Loeb Institute for Medical Research, University of Ottawa, Ottawa
Thomas N. Chase
Affiliation:
Institute of Mental Health Research, University of Ottawa, Ottawa
*
Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4
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Abstract:

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Patients with predominantly unilateral parkinsonian signs may provide a unique opportunity to evaluate the cerebral representation of cognitive functions characteristically affected in idiopathic Parkinson’s disease. Twenty hemiparkinsonian patients (ten left and ten right) and 10 healthy controls, matched for age and education, were studied with neuropsychological tests and positron emission tomography. Both right and left hemiparkinsonians evidenced impairments in visuospatial and verbal episodic memory function, but had no deficits in executive abilities, compared to controls. None of the neuropsychological test scores distinguished right from left hemiparkinsonians. Glucose metabolic profiles were identical for the three groups in all cortical areas assessed; in the subcortex however, lenticular hypermetabolism contralateral to the predominant side of motor involvement was evident in the left hemiparkinsonian group. Correlational analysis revealed that higher glucose metabolic rates in the basal ganglia of these hemiparkinsonians were associated with lower visuospatial test scores. In frontal and parietal cortex, decreasing glucose metabolism was positively associated with neurobehavioral function; in temporal cortex, measures of attention and memory decreased with increasing glucose metabolic rates.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 2 , May 1992 , pp. 163 - 169
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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