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Neuropathic Pain: Redundant Pathways, Inadequate Therapy

Published online by Cambridge University Press:  02 December 2014

Douglas Zochodne*
Affiliation:
Department of Clinical Neurosciences and the Hotchkiss Brain Institute University of Calgary, Calgary, Alberta, Canada
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Abstract

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Type
Editorial
Copyright
Copyright © The Canadian Journal of Neurological 2012

References

1.Stemkowski, PL, Smith, PA.Sensory neurons, ion channels, inflammation and the onset of neuropathic pain. Can J Neurol Sci. 2012;39(4):41635.CrossRefGoogle ScholarPubMed
2.Willis, DE, Twiss, JL.The evolving roles of axonally synthesized proteins in regeneration. Curr Opin Neurobiol. 2006 Feb;16:11118.CrossRefGoogle ScholarPubMed
3.Zhang, X, Meister, B, Elde, R, Verge, VMK, Hokfelt, T.Large calibre primary afferent neurons projecting to the gracile nucleus express neuropeptide Y after sciatic nerve lesions: an immunohistochemical and in situ hybridization study in rats. Eur J Neurosci. 1993;5:151019.CrossRefGoogle Scholar
4.Verge, VMK, Gratto, KA, Karchewski, LA, Richardson, PM.Neurotrophins and nerve injury in the adult. Philos Trans R Soc Lond B Biol Sci. 1996;351:42330.Google ScholarPubMed
5Coull, JA, Beggs, S, Boudreau, D, et al.BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005 Dec 15;438:101721.Google Scholar
6Tsuda, M, Inoue, K, Salter, MW.Neuropathic pain and spinal microglia: a big problem from molecules in “small” glia. Trends Neurosci. 2005 Feb;28:1017.Google Scholar
7Beggs, S, Salter, MW.Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0. Curr Opin Neurobiol. 2010 Aug;20:47480.CrossRefGoogle ScholarPubMed
8Zhuo, M.Canadian Association of Neuroscience review: cellular and synaptic insights into physiological and pathological pain. EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health lecture. Can J Neurol Sci. 2005 Feb;32:2736.CrossRefGoogle Scholar
9Hudson, AJ.Pain perception and response: central nervous system mechanisms. Can J Neurol Sci. 2000 Feb;27:216.CrossRefGoogle ScholarPubMed
10Treede, RD, Jensen, TS, Campbell, JN, et al.Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008 Apr 29;70:16305.CrossRefGoogle Scholar
11Sommers, CJ, Zochodne, DW.Case studies in neurological pain. Cambridge Press, 2012 [in press].Google Scholar
12Bril, V, England, J, Franklin, GM, et al.Evidence-based guideline: treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2011 May 17;76:175865.Google Scholar
13Dworkin, RH, O’Connor, AB, Audette, J, et al.Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010 Mar;85:S314.CrossRefGoogle ScholarPubMed
14Attal, N, Cruccu, G, Haanpaa, M, et al.EFNS guidelines on pharmacological treatment of neuropathic pain. Eur J Neurol. 2006 Nov;13:115369.Google Scholar
15Toth, C, Lander, J, Wiebe, S.The prevalence and impact of chronic pain with neuropathic pain symptoms in the general population. Pain Med. 2009 Jul;10:91829.CrossRefGoogle ScholarPubMed