Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-13T01:08:32.377Z Has data issue: false hasContentIssue false
  • English
  • Français

The Neurapraxic Lesion: A Clinical Contribution to the Study of Trophic Mechanisms

Published online by Cambridge University Press:  18 September 2015

A. J. McComas ,
P. B. Jorgensen  and
A. R. M. Upton
A. J. McComas*
Affiliation:
Department of Medicine (Neurology) and the Medical Research Council's Developmental Neurobiology Research Group; McMaster University Medical Centre, 1200 Main St. W., Hamilton, Ontario
P. B. Jorgensen
Affiliation:
Department of Medicine (Neurology) and the Medical Research Council's Developmental Neurobiology Research Group; McMaster University Medical Centre, 1200 Main St. W., Hamilton, Ontario
A. R. M. Upton
Affiliation:
Department of Medicine (Neurology) and the Medical Research Council's Developmental Neurobiology Research Group; McMaster University Medical Centre, 1200 Main St. W., Hamilton, Ontario
*
McMaster University Medical Centre, 1200 Main St. W., Hamilton, L8S 4J9, Ontario, Canada.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Four patients with neurapraxic lesions are described; in spite of the absence of impulse activity in muscle fibers no other signs of denervation could be detected. These observations are interpreted as indirect evidence for the role o f a non-impulsive (axoplasmic flow) system in certain trophic phenomena. The relationship of the present findings to the spectrum of neuropathic lesions is considered.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 1 , Issue 3 , August 1974 , pp. 170 - 179
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

References

Denny-Brown, D. and Brenner, C. (1944). Paralysis of nerve induced by direct pressure and by tourniquet. Archives of Neurology and Psychiatry, 51, 1–26.CrossRefGoogle Scholar
Erb, W. H. (1896). Diseases of the peripheral cerebrospinal nerves. In Von Ziemssen, H. W., Cyclopaedia of the Practice of Medicine, Vol. 11 New York: William Wood. Cited by Denny-Brown, and Brenner, C. in Archives of Neurology and Psychiatry, 51, 1–26 (1944).Google Scholar
Drachmán, D. B. (1974), editor, Trophic Functions of the Neuron (Symposium). Annals of the New YorkAcademy of Sciences, 228, 1–423.Google Scholar
Guth, L. (1968). Trophic influences of nerve on muscle. Physiological Reviews, 48, 645–687.CrossRefGoogle ScholarPubMed
Gutmann, E., Schiaffino, S. and Hanzlíkova, V. (1971). Mechanism of compensatory hypertrophy in skeletal muscle of the rat. Experimental Neurology, 31, 451–464.CrossRefGoogle ScholarPubMed
Lapresle, J., Fardeau, M. and Said, G. (1973). L'hypertrophie musculaire vraie secondaire à une atteinte nerveuse périphérique. Etude clinique et histologique d'une observation d'hypertrophie du mollet consécutive à une sciatique. Revue neurologique, 128, 153–160.Google Scholar
Mccomas, A. J., Sica, R. E. P. and Upton, A. R. M. (1974). Multiple muscle analysis of motor units in muscular dystrophy. Archives of Neurology, 30, 249–251.CrossRefGoogle ScholarPubMed
Mccomas, A. J., Fawcett, P. R. W., Campbell, M. J. and Sica, R. E. P. (1971). Electrophysiological estimation of the number of motor units within a human muscle. Journal of Neurology, Neurosurgery and Psychiatry, 34, 121–131.CrossRefGoogle Scholar
Miledi, R. and Slater, C. R. (1970). On the degeneration of rat neuromuscular junctions after nerve section. Journal of Physiology, 207, 507–528.CrossRefGoogle ScholarPubMed
Rasminsky, M. and Sears, T. A. (1972). Internodal conduction in undissected de-myelinated nerve fibers. Journal of Physiology, 227, 323–350.CrossRefGoogle Scholar
Seddon, H. J. (1943). Three types of nerve injury. Brain, 66, 237–288.CrossRefGoogle Scholar
Sica, R. E. P., Mccomas, A. J., Upton, A. R. M. and Longmire, D. (1974). Motor unit estimations in small muscles of the hand. Journal of Neurology, Neurosurgery and Psychiatry, 37, 55–67.Google ScholarPubMed
Sunderland, S. (1951). A classification of peripheral nerve injuries producing loss of function. Brain, 74, 491–516.CrossRefGoogle ScholarPubMed
Upton, A. R. M. and Mccomas, A. J. (1973). The double crush hypothesis in nerve entrapment syndromes. Lancet, 2, 359–362.CrossRefGoogle Scholar