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Myasthenia Gravis Associated with Diphenylhydantoin Therapy For Epilepsy

Published online by Cambridge University Press:  18 September 2015

Joel Brumlik  and
Robert S. Jacobs
Joel Brumlik*
Affiliation:
Departments of Neurology and Pharmacology and Therapeutics, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153
Robert S. Jacobs
Affiliation:
Departments of Neurology and Pharmacology and Therapeutics, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153
*
Neurology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, U.S.A
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Summary

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A young woman with epilepsy developed myasthenic symptoms while taking diphenylhydantoin. The clinical, electromyographic and pharmacologic findings were consistent with myasthenia gravis. Symptoms of myasthenia ceased on withdrawal of the drug, and recurred on readministration, with little apparent relationship to serum phenytoin levels. This unusual effect is discussed with reference to the known effects of diphenylhydantoin at the neuromyal junction.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 1 , Issue 2 , May 1974 , pp. 127 - 129
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

References

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