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Modafinil in Endozepine Stupor. A Case Report

Published online by Cambridge University Press:  02 December 2014

Sharon Scott  and
Iftekhar Ahmed
Sharon Scott
Affiliation:
Department of Family Practice, Trinity Lutheran Hospital, Kansas City, Missouri, USA
Iftekhar Ahmed
Affiliation:
Department of Neurology, Research Medical Center and Department of Neurology, University of Missouri, Kansas City, Missouri, USA
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Abstract

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Background:

Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit.

Method:

We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor.

Results:

The vigilance promoting drug modafinil prevented recurrent episodes of stupor and coma in this patient at a dose of 200 mg/day for a period of six months. Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year.

Type
Editorial
Information
Canadian Journal of Neurological Sciences , Volume 31 , Issue 3 , August 2004 , pp. 409 - 411
Copyright
Copyright © The Canadian Journal of Neurological 2004

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