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Lymphocytic Hypophysitis with a Long Latent Period Before Development of a Pituitary Mass

Published online by Cambridge University Press:  02 December 2014

Rene W.G. Wong ,
Teik Chye Ooi ,
Brien Benoit ,
David Zackon ,
Gerard Jansen  and
Adam Telner
Rene W.G. Wong
Affiliation:
Division of Endocrinology and Metabolism, Ottawa Hospital, University of Ottawal, Ottawa, Ontario, Canada
Teik Chye Ooi
Affiliation:
Division of Endocrinology and Metabolism, Ottawa Hospital, University of Ottawal, Ottawa, Ontario, Canada
Brien Benoit
Affiliation:
Division of Neurosurgery, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
David Zackon
Affiliation:
Division of Neuro-ophthalmology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
Gerard Jansen
Affiliation:
Division of Pathology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
Adam Telner
Affiliation:
Department of Medicine, Queensway-Carleton Hospital, Ottawa, Ontario, Canada
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Abstract

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Background:

Lymphocytic hypophysitis is an autoimmune condition that commonly presents in women of childbearing age as hypopituitarism and a sellar mass.

Case report:

A 66-year-old woman presented with anterior pituitary dysfunction. Computed tomography imaging revealed a small hypodensity that was not felt to be the cause of the pituitary dysfunction. Eight years later, her vision rapidly deteriorated and MRI showed a pituitary mass lesion causing optic chiasm compression. Histological examination of the partially resected gland revealed evidence of lymphocytic hypophysitis.

Conclusion:

Our patient is an example of the variable presentation and course of lymphocytic hypophysitis. Such a long latent period between the initial presentation of adenohypophysial hypofunction and optic chiasm compression due to an enlarging pituitary mass has not been reported.

Type
Editorial
Information
Canadian Journal of Neurological Sciences , Volume 31 , Issue 3 , August 2004 , pp. 406 - 408
Copyright
Copyright © The Canadian Journal of Neurological 2004

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