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Long Term Induction of Kindled Seizures in Rats: Interhemispheric Factors

Published online by Cambridge University Press:  18 September 2015

José N. Nobrega  and
John Gaito
José N. Nobrega*
Affiliation:
Department of Psychology, York University
John Gaito
Affiliation:
Department of Psychology, York University
*
4700 Keele St., Downsview, Ontario, Canada M3J 1P3.
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Previous research indicated that sequential alternation of stimulation of certain homologous brain areas via chronically implanted electrodes resulted in oscillation of high and low latencies for convulsions. This phenomenon suggested the establishment of interhemispheric facilitatory-inhibitory effects as a result of repeated stimulation of the two brain sites. In the present study, the latency oscillation pattern was observed in split-brain rats as well as in bilaterally stimulated controls, but not in rats stimulated on one side only. Significant differences were observed between split-brain and control rats in terms of initial kindling rates, duration of convulsions and type of oscillation. Results are discussed in the context of possible interhemispheric mechanisms involved in long term kindling.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 2 , May 1978 , pp. 223 - 230
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

REFERENCES

Cullen, N., and Goddard, G.V. (1975). Kindling in the hypothalamus and transfer to the ipsilateral amygdala. Behavioral Biology. 15, 119–131.CrossRefGoogle Scholar
Gaito, J. (1974). The kindling effect. Physiological Psychology, 2, 45–50.CrossRefGoogle Scholar
Gaito, J., (1976). An oscillation effect during sequential alternation of unilateral amygdaloid stimulation within the kindling paradigm. Physiological Psychology, 4, 303–306. (a).CrossRefGoogle Scholar
Gaito, J. (1976). The effect of number of trials per day during sequential alternation of unilateral amygdaloid stimulation. Bulletin of the Psychonomic Society, 4. 403–404. (b).CrossRefGoogle Scholar
Gaito, J. (1976). The effect of varying rest intervals following the development of oscillation during unilateral amygdaloid stimulation. Bulletin of the Psychonomic Society, 8. 457–458. (c).CrossRefGoogle Scholar
Gaito, J. (1977). The effect of intensity during sequential alternation of unilateral amygdaloid stimulation. Bulletin of the Psychonomic Society, 9. 64–66.CrossRefGoogle Scholar
Gaito, J., and Nobrega, J. (1977). The oscillation effect during sequential alternation of amygdaloid stimulation with aged rats. Bulletin of the Psychonomic Society, 9, 151–154.CrossRefGoogle Scholar
Gaito, J., Gaito, S.T., and Nobrega, J., (1977). A factor analysis on data from 10 phases of sequential alternation. Physiological Psychology. 3, 300–310.CrossRefGoogle Scholar
Goddard, G.V., and Douglas, R.M. (1975). Does the engram of kindling model the engram of normal long term memory? Canadian Journal of Neurological Sciences. 2, 385–394.CrossRefGoogle ScholarPubMed
Goddard, G.V., McIntyre, D.C, and Leech, C.K.,(1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25. 295–300.CrossRefGoogle ScholarPubMed
Hoel, P.G. (1954). Introduction to mathematical statistics. New York: Wiley.Google Scholar
McCaughran, J.A., Corcoran, M.E., and Wada, J.A.Development of kindled amygdaloid seizures after section of the forebrain commissures in rats. Folia Psychiatrica et Neurologia Japonica, 30, 65–71.Google Scholar
McIntyre, D.C., (1975). Split-brain rat: transfer and interference of kindled amygdala convulsions. Canadian Journal of Neurological Sciences. 2, 429–437.CrossRefGoogle ScholarPubMed
McIntyre, D.C, and Goddard, G.V., (1973). Transfer, interference and spontaneous recovery of convulsions kindled from the rat amygdala. Electroencephalography and Clinical Neurophysiology, 35, 533–543.CrossRefGoogle ScholarPubMed
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle ScholarPubMed
Tress, K., and Herberg, L.J., (1972). Permanent reduction in seizure threshold resulting from repeated electrical stimulation. Experimental Neurology, 37, 347–359.CrossRefGoogle ScholarPubMed
Wada, J.A., and Sato, M., (1975). The generalized convulsive state induced by daily electrical stimulation of the amygdala in split brain cats. Epilepsia, 16, 417–430.CrossRefGoogle ScholarPubMed