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Lissencephaly

Published online by Cambridge University Press:  18 September 2015

Margaret G. Norman ,
Maureen Roberts ,
J. Sirois  and
L.J.M. Tremblay
Margaret G. Norman*
Affiliation:
Divisions of Pathology and Genetics, Eleanor M. Paterson Laboratory, Children's Hospital of Eastern Ontario, Ottawa, and Departments of Pathology and Pediatrics, University of Ottawa, Ontario; and Departments of Pathology, Sacre Coeur Hospital, Hull, Quebec and St. Andrews Hospital, Midland, Ontario
Maureen Roberts
Affiliation:
Divisions of Pathology and Genetics, Eleanor M. Paterson Laboratory, Children's Hospital of Eastern Ontario, Ottawa, and Departments of Pathology and Pediatrics, University of Ottawa, Ontario; and Departments of Pathology, Sacre Coeur Hospital, Hull, Quebec and St. Andrews Hospital, Midland, Ontario
J. Sirois
Affiliation:
Divisions of Pathology and Genetics, Eleanor M. Paterson Laboratory, Children's Hospital of Eastern Ontario, Ottawa, and Departments of Pathology and Pediatrics, University of Ottawa, Ontario; and Departments of Pathology, Sacre Coeur Hospital, Hull, Quebec and St. Andrews Hospital, Midland, Ontario
L.J.M. Tremblay
Affiliation:
Divisions of Pathology and Genetics, Eleanor M. Paterson Laboratory, Children's Hospital of Eastern Ontario, Ottawa, and Departments of Pathology and Pediatrics, University of Ottawa, Ontario; and Departments of Pathology, Sacre Coeur Hospital, Hull, Quebec and St. Andrews Hospital, Midland, Ontario
*
Children's Hospital of Eastern Ontario, 401 Smyth Rd. Ottawa, Ont. K1H 8L1 Canada
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The first reported case of lissencephaly resulting from a consanguinous union strengthens the supposition that in some cases, it is transmitted as an autosomal recessive trait. Comparison of this case with a sporadically occuring case of lissencephaly, with different cortical morphology, suggests that lissencephaly may be an example of either varying gene expressivity or gene-tic heterogeneity. Lissencephaly and pachygyria may eventually be shown to be due to different causes, some inherited, some acquired. The classical examples of lissencephaly are different morphologically from a case in which antenatal cytomegalovirus infection had produced a small smooth brain. This suggests that antenatal viral infections are destructive rather than teratogenic.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 1 , February 1976 , pp. 39 - 46
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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