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Late Progression of Post-Encephalitic Parkinson's Syndrome

Published online by Cambridge University Press:  18 September 2015

Donald B. Calne  and
Andrew J. Lees
Donald B. Calne*
Affiliation:
Belzberg Laboratory of Clinical Neuroscience, University of British Columbia, Vancouver, British Columbia
Andrew J. Lees
Affiliation:
The National Hospital for Nervous Diseases, Queen Square, London, England
*
Division of Neurology, U.B.C., Health Sciences Centre Hospital, 2211 Westbrook Mall, Vancouver, British Columbia, Canada V6T IW5
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Abstract:

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We have studied 11 patients with neurological deficits due to the pandemic of encephalitis lethargica, all of whom had remained in hospital for more than forty years. Retrospective information obtained from physicians and nurses dating back as far as 1931, our own Webster and Northwestern University Disability Rating Scales available from 1976, photographic records, published narrative and hospital charts all indicate that neurological disabilities attributable to basal ganglia damage frequently increase in late life. Deterioration was most marked in motor function and largely spared the intellect, special senses and somatosensory system. The findings are discussed in relation to current hypotheses concerning the aetiology of Parkinson's disease.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 2 , May 1988 , pp. 135 - 138
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

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