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Kindling: Secondary Epileptogenesis, Sleep and Catecholamines

Published online by Cambridge University Press:  18 September 2015

Mitsumoto Sato  and
Toyoji Nakashima
Mitsumoto Sato*
Affiliation:
Department of Neuropsychiatry, School of Medicine, Okayama University
Toyoji Nakashima
Affiliation:
Department of Neuropsychiatry, School of Medicine, Okayama University
*
Department of Neuropsychiatry, School of Medicine, Okayama University Hospital, Okayama City, Japan
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Seizure development and transference phenomenon were investigated in hippocampal and amygdaloid kindled cats. The behavioral and electrographic findings during the kindling procedures showed that motor seizure development in hippocampal seizures occurred with the emergence of independent discharging in the amygdala, globus pallidus and contralateral hippocampus. Furthermore, secondary site convulsions developed upon the first stimulation of these structures in the hippocampal group but only after over a month of hippocampal stimulation in the amygdaloid group. It was, therefore, concluded that role of the amygdala and globus pallidus in hippocampal seizure development was more essential than that of hippocampal stimulation in amygdaloid seizure development. The common findings between the hippocampal and amygdaloid kindled animals were the systematic progression to seizures, the all-or-nothing nature of the electrical response and the relative permanency of the seizure susceptibility. Seizure susceptibility increased during slow wave sleep and decreased during REM sleep. These latter findings were examined with preliminary data of brain bioassays of catecholamines.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 439 - 446
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

Arnold, P.S.Racine, R.J. and Wise, R.A. (1973). Effects of atropine, reserpine, 6-hydroxydopamine. and handling on seizure development in the rat. Experimental Neurology, 40, 457–470.CrossRefGoogle ScholarPubMed
Boggan, W.O. and Seiden, L.S. (1971). Dopa reversal of reserpine enhancement of audiogenic seizure susceptibility in mice. Physiology and Behavior, 6, 215–217.CrossRefGoogle ScholarPubMed
Bourn, W.M.Chin, L. and Picchioni, A.L. (1972). Enhancement of audiogenic seizure by 6-hydroxydopamine. Journal of Pharmacy and Pharmacology, 24, 913–914.CrossRefGoogle ScholarPubMed
Buser, P.Bancaud, J.Talairach, A.L. and Szikla, G. (1969). Amygdalohippocampal interconnections in man. Physiological study during stereotaxic explorations. Electroencephalography and Clinical Neurophysiology, 26, 637.Google ScholarPubMed
Cadilhac, J. and Passonant, P. (1964). Influence of various phases of night sleep in the epileptic discharges in man. Electroencephalography and Clinical Neurophysiology, 17, 441.Google Scholar
Cohen, H.Thomas, J. and Dement, W.C. (1970). Sleep stages, REM deprivation and electroconvulsive threshold in the cats. Brain Research, 19, 317–321.CrossRefGoogle Scholar
Corcoran, M.E.Fibiger, H.C.McCaughran, J.A. and Wada, J.A. (1974). Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats. Experimental Neurology, 45, 118–133.CrossRefGoogle ScholarPubMed
Frank, G. (1970). Epileptiform discharge in the various stages of sleep. Electroencephalography and Clinical Neurophysiology, 28, 90–105.Google ScholarPubMed
Fujimori, F. (1966). Electroencephalographic study on the focal seizure discharges during nocturnal sleep of epileptics (in Japanese). Psychiatria et Neurologia Japonica. 68. 330–350.Google Scholar
Goddard, G.V. (1972). Long term alteration following amygdaloid stimulation. In: The Neurobiology of the Amygdala, p. 581–596, Plenum Publishing Corporation, New York.CrossRefGoogle Scholar
Goddard, G.V.McIntyre, D.C. and Leech, C.K. (1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25, 295–330.CrossRefGoogle ScholarPubMed
Hayashi, A. (1966). An experimental study on the relationship between the epileptic seizure discharge and natural sleep stages (in Japanese). Psychiatria et Neurologia Japonica, 68, 351–379.Google Scholar
Izumi, K.Donaldson, J.Minnich, J. and Barbeau, A. (1973). Ouabain induced seizures in rats: Relation to brain monoamines. Canadian Journal of Biochemistry. 51, 198–203.CrossRefGoogle Scholar
Janz, D. (1962). The grand mal epilepsies and the sleeping-waking cycle. Epilepsia (Amst.), 3, 69–109.CrossRefGoogle ScholarPubMed
Mcintyre, D.C. amd Molino, A. (1972). Amygdala lesions and CER learning longterm effect of kindling. Physiology and Behavior, 8, 1055–1058.CrossRefGoogle Scholar
McIntyre, D.C. and Goddard, G.V. (1973). Transfer, interference and spontaneous recovery of convulsions kindled from the rat amygdala. Electroencephalography and Clinical Neurophysiology, 35, 533–543.CrossRefGoogle ScholarPubMed
McKenzie, G.M. and Soroko, F.E. (1972). (+)-amphetamine and 1-dopa on maximal electroshock convulsions — a comparative study in the rat and mouse. Journal of Pharmacy and Pharmacology, 24, 696–701.CrossRefGoogle Scholar
Popoviciu, L.Szabo, L. and Borchina, N. (1971). Electropolygraphical all night sleep in certain form of epilepsy. Electroencephalography and Clinical Neurophysiology, 30, 361.Google Scholar
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation: I. After-discharge threshold. Electroencephalography and Clinical Neurophysiology, 32, 269–279.CrossRefGoogle ScholarPubMed
Racine, R.J. (1972). Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281–294.CrossRefGoogle ScholarPubMed
Racine, R.J.Gartner, J.G. and Mcintyre, B.W. (1972). Epileptiform activity and plasticity in limbic structures. Brain Research, 47, 262–268.CrossRefGoogle ScholarPubMed
Sato, M. (1975). An experimental study of epilepsy with “kindling effect” procedure — I. Behavioral and electroencephalographic study on the developmental process of hippocampal seizure (in Japanese). Psychiatria et Neurologia Japonica, 77, in press.Google Scholar
Sato, M. (1975). An experimental study of epilepsy with “kindling effect” procedure — II. Study on the secondary epileptogenesis of the hippocampal seizure with “transference phenomenon” (in Japanese). Psychiatria et Neurologia Japonica, 77, in press.Google Scholar
Sato, M.Onishi, T.Nakashima, T.Uefuji, K.Takahashi, Y. and Otsuki, S. (1974). Influence of sleep-arousal levels on the hippocampal inter-ictal discharge(in Japanese). Medicine and Biology, 89, 251–256.Google Scholar
Sato, M. and Wada, J.A. (1975). Review on the kindling preparation: A new experimental model of epilepsy (in Japanese). Brain and Nerve, 27, 257–276.Google Scholar
Sato, M.Nakashima, T.Otsuki, S.Kishikawa, H. and Kobayashi, K. (1975). Change of brain catecholamine levels in the kindling preparation of cats (in Japanese). Igakuno Ayumi, 92, in press.Google Scholar
Wada, J.A. and Sato, M. (1974) Generalized convulsive seizure induced by daily electrical stimulation of the amygdala in cats: Correlative electrographic and behavioral features. Neurology, 24, 565–574.CrossRefGoogle ScholarPubMed
Wada, J.A.Sato, M. and Corcoran, M.E. (1974). Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats. Epilepsia (Amst.), 15, 465–478.CrossRefGoogle ScholarPubMed
Wilczak, H. (1970). Influence of various phases of night sleep on the epileptic discharges in man (in Polish). Psychiatria Polska, 4, 31–36.Google Scholar