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Ischemic Neuronal Injury is Ameliorated by Astrocyte Activation

Published online by Cambridge University Press:  18 September 2015

Deon F. Louw ,
Tetsuy Masada  and
Garnette R. Sutherland
Deon F. Louw
Affiliation:
Department of Clinical Neurosciences, The University of Calgary, Calgary, Canada
Tetsuy Masada
Affiliation:
Department of Neurological Surgery and Physiology, Kagawa Medical School, Kagawa, Japan
Garnette R. Sutherland*
Affiliation:
Department of Clinical Neurosciences, The University of Calgary, Calgary, Canada
*
75 Bruyere Street, Ottawa, Ontario, Canada K1N 5C8
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Abstract:

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Background:

The motivation of this study was to more precisely define the in vivo role of astrocytes in forebrain ischemia. Controversy exists in the literature as to whether they protect or injure neurons in this setting.

Methods:

Astrocytes in the rat hippocampus were disabled with stereotactic administration of a gliotoxin, ethidium bromide, 3 days prior to induction of forebrain ischemia. The extent of neuronal injury in this group was compared to a control category receiving intrahippocampal saline only.

Results:

Saline-injected animals demonstrated decreased hippocampal CA1 sector injury, and increased gliosis on the side of the injection compared to the contralateral side (P < 0.01) or ethidium bromide-treated animals (P < 0.05).

Conclusion:

The results suggest that activated astrocytes are protective to neurons subjected to an ischemic insult. This may result from their ability to elaborate neurotrophic factors, buffer potassium and metabolize a variety of neurotransmitters.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 25 , Issue 2 , February 1998 , pp. 102 - 107
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

References

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