Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-19T06:06:12.316Z Has data issue: false hasContentIssue false
  • English
  • Français

Is Parkinson’s Disease Acquired or Inherited?

Published online by Cambridge University Press:  18 September 2015

Roger C. Duvoisin
Roger C. Duvoisin*
Affiliation:
Department of Neurology, UMDNJ-Rutgers Medical School, New Brunswick, N.J
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A considerable proportion of patients with Parkinson’s disease report having affected relatives. However, anamnestic data obtained from probands on the occurrence of secondary cases among their relatives are of limited value. In considering the possible role of heredity in Parkinson’s disease it is necessary to carefully distinguish between the disease and other disorders such as essential tremor and olivopontocerebellar atrophy which may manifest parkinsonian features. Controlled family studies have shown only a very slight excess of secondary cases among index siblings as compared to spouse siblings. The concordance rate for Parkinson’s disease among identical twins is extraordinarily low and does not significantly exceed that among fraternal twins or that expected from the prevalence rate among siblings found in the controlled family studies. The available evidence indicates that heredity plays no significant role in the etiology of Parkinson’s disease. Consequently the disease must be considered to be acquired.

Type
3. Genetic Factors and Epidemiology of Parkinson’s Disease
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 151 - 155
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Allan, W (1927) Inheritance of the Shaking Palsy. Arch. Int. Med. 60: 424–436.CrossRefGoogle Scholar
Barbeau, A, Pourcher, E (1982) New data on the genetics of Parkinson’s disease. Can. J. Neurol. Sci. 4: 53–60.CrossRefGoogle Scholar
Bell, J, Clark, AJ (1926) A Pedigree of Paralysis Agitans. Ann. Eugen. I: 445–462.Google Scholar
Clough, CG, Mendoza, M, Yahr, MD (1981) A Case of Sporadic Juvenile Parkinson’s Disease. Arch. Neurol. 38: 730–731.CrossRefGoogle ScholarPubMed
Critchley, M (1949) Observations on essential (heredofamilial) tremor. Brain 72: 113–139.CrossRefGoogle Scholar
Duvoisin, RC, Gearing, FR, Schweitzer, MD, Yahr, MD (1969) A Family Study of Parkinsonism. In: Barbeau, A. and Brunette, J.R., eds. Progress in Neurogenetics. Amsterdam, Excerpta Medica, pp. 492–496.Google Scholar
Duvoisin, RC, Eldridge, R, William, A, Nutt, J, Calne, DB (1981) Twin Study of Parkinson Disease. Neurology 31: 77–80.CrossRefGoogle ScholarPubMed
Falconer, DS (1965) The inheritance of liability to certain diseases estimated from the incidence among relatives. Ann. Human Genet. 29: 51–76.CrossRefGoogle Scholar
Hearer, AF, Anderson, UW, Schoenberg, BS (1982) Prevalence of essential tremor. Arch. Neurol. 39: 750–752.CrossRefGoogle Scholar
Hart, TS (1904) Paralysis Agitans: Some clinical observations based on the study of 219 cases at the clinic of Professor M. Allen Starr. J. Nerv. Ment. Dis. 31: 177–178.CrossRefGoogle Scholar
Hoehn, MM (1976) Age distribution of patients with parkinsonism. J. Am. Ger. Soc. 24: 79–85.CrossRefGoogle ScholarPubMed
Kessler, II (1978) Parkinson’s disease in epidemiological perspective. Adv. Neurology. 19: 355–383.Google Scholar
Kondo, K, Kurland, LT, Schull, WJ (1973) Parkinson’s disease, genetic analysis and evidence of a multi-factorial etiology. Mayo Clin. Proc. 48:465–475.Google Scholar
Kurland, LT (1958) Epidemiology: Incidence. Geographic Distribution and Genetic Consideration. In: Fields, W., ed. Pathogenesis and Treatment of Parkinsonism. Springfield, Chas. C. Thomas, pp. 5–49.Google Scholar
Larsen, TA, Calne, DB (1983) Essential Tremor. Clin. Neuropharmacol. 6: 184–206.CrossRefGoogle ScholarPubMed
Larsson, T, Sjogren, T (1960). Essential Tremor: A Clinical and Genetic Population Study. Acta Psychiatria Scand. 36, Supp. 144: 1–176.Google ScholarPubMed
Mjones, H (1949) Paralysis Agitans. A Clinical Genetic Study. Acta Psychiat. et Neurol. Scand. 25, Suppl. 54: 1–195.Google Scholar
Martin, WE, Young, WI, Anderson, VE (1973). Parkinson’s Disease, A Genetic Study. Brain 96: 495–506.CrossRefGoogle ScholarPubMed
Rajput, AJ, Elveback, LR, Beard, CM, Kurland, LT (1981). Epidemiology of Parkinson’s disease in Rochester, Minnesota. Paper presented at 12th World Congress for Neurology, Kyoto, Japan, Sept. 1981. International Congress Series 548, Amsterdam, Excerpta Medical. Abstract 47.Google Scholar
Rautakorpi, I, Takala, J, Marttila, RJ, Sievers, K, Rinne, VK (1978) Essential tremor in a Finnish population. Acta Neurol. Scand. 66: 58–67.CrossRefGoogle Scholar
Rosati, G, Granieri, E, Pinna, L., Aiello, I.Tola, Ret al. (1980) The risk of Parkinson disease in Mediterranean people. Neurology 30: 250–255.CrossRefGoogle ScholarPubMed
Roy, M, Boyer, L, Barbeau, A (1983) A study of 50 cases of familial Parkinson’s disease. Can. J. Neurol. Sci. 10: 37–42.CrossRefGoogle ScholarPubMed
Scarpalezos, S (1948) Sur la notion d’heredite similaire dans la maladie de Parkinson. Rev. Neurologique 80: 184–203.Google Scholar
Spellman, GG (1962) Report of familial cases of parkinsonism. J. Am. Med. Assoc. 179: 160–162.CrossRefGoogle ScholarPubMed
Ward, CD, Duvoisin, RC, Ince, SE, Nutt, JD, Eldridge, R, Calne, DB (1983) Parkinson’s disease in 65 pairs of twins and in a set of quadruplets. Neurology 33: 815–824.CrossRefGoogle Scholar