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Inverse Vaccination to Silence Immunity to Myelin in Multiple Sclerosis

Published online by Cambridge University Press:  02 December 2014

Lawrence Steinman
Lawrence Steinman*
Affiliation:
Department of Neurological Sciences and Interdepartmental Program in Immunology, Stanford University, Stanford, California, USA.
*
Department of Neurological Sciences and Interdepartmental Program in Immunology, Stanford University, Stanford, California, 94305, USA.
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Abstract:

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The adaptive immune response in multiple sclerosis is complex. We have devised large scale arrays to measure the antibody response to myelin proteins and lipids. Despite the widespread immune responses to myelin, we have devised an inverse vaccine aimed at turning off key drivers of this diverse response. Clinical trials in patients with multiple sclerosis show that it is possible to constrain antibody responses to myelin on a large scale with this approach.

Résumé:

RÉSUMÉ:

La réponse immunitaire d'adaptation dans la sclérose en plaques est complexe. Nous avons créé des biopuces pour mesurer la réponse immunitaire aux protéines et aux lipides de la myéline. Même si la réponse immunitaire à la myéline est largement répandue, nous avons conçu un vaccin inverse dans le but d'abolir les éléments nourriciers clés de cette réponse hétérogène. Des essais cliniques chez des patients atteints de sclérose en plaques ont montré qu'il est possible de réprimer la production d'anticorps dirigés contre la myéline sur une grande échelle en utilisant cette approche.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 37 , supplement S2 , September 2010 , pp. S49 - S58
Copyright
Copyright © Canadian Neurological Sciences Federation 2010

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