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Intraventricular Alpha Interferon Therapy for Rasmussen’s Syndrome

Published online by Cambridge University Press:  18 September 2015

L. Maria Bernard ,
M. Ringdahl Debbie ,
J. Parker Mickle ,
J. Smith Linda ,
D. Reuman Peter ,
L. Gilmore Robin ,
E. Drane Walter  and
G. Quisling Ronald
L. Maria Bernard*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
M. Ringdahl Debbie*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
J. Parker Mickle*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
J. Smith Linda*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
D. Reuman Peter*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
L. Gilmore Robin*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
E. Drane Walter*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
G. Quisling Ronald*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
*
Division of Pediatric Neurology, University of Florida College of Medicine, P.O. Box 100296, J.H.M. Health Center, Gainesville, Florida, U.S.A. 32610-0296
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Abstract:

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A 4-year-old boy developed Rasmussen’s syndrome and was treated with alpha interferon intraventricularly. An improvement in the epileptic and neurologic syndrome was noted for several weeks following interferon. No adverse side effects were encountered. Since hemispherectomy is the only established therapy in Rasmussen’s Syndrome, further studies are needed to establish if intraventricular alpha interferon may halt the clinical progression of the syndrome.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 4 , November 1993 , pp. 333 - 336
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

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