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Intraventricular Alpha Interferon Therapy for Rasmussen’s Syndrome

Published online by Cambridge University Press:  18 September 2015

L. Maria Bernard*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
M. Ringdahl Debbie*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
J. Parker Mickle*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
J. Smith Linda*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
D. Reuman Peter*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
L. Gilmore Robin*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
E. Drane Walter*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
G. Quisling Ronald*
Affiliation:
Division of Pediatric Neurology (B.L.M., D.M.R.), Division of Pediatric Infectious Diseases (P.D.R.), and the Departments of Neurosurgery (I.P.M.), Neurology (R.L.G.), Laboratory Medicine (L.J.S.), and Radiology (R.G.Q., W.E.D.), University of Florida College of Medicine, Gainesville, Florida
*
Division of Pediatric Neurology, University of Florida College of Medicine, P.O. Box 100296, J.H.M. Health Center, Gainesville, Florida, U.S.A. 32610-0296
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Abstract:

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A 4-year-old boy developed Rasmussen’s syndrome and was treated with alpha interferon intraventricularly. An improvement in the epileptic and neurologic syndrome was noted for several weeks following interferon. No adverse side effects were encountered. Since hemispherectomy is the only established therapy in Rasmussen’s Syndrome, further studies are needed to establish if intraventricular alpha interferon may halt the clinical progression of the syndrome.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Rasmussen, T, Olszweske, J, Lloyd-Smith, D.Focal seizures due to chronic localized encephalitis. Neurology 1958; 8: 435445.Google Scholar
2.Dalos, N, Vining, E, Carson, B, et al. Rasmusseni encephalitis: clinical recognition and surgical management. Ann Neurol 1986; 20: 434.Google Scholar
3.Zupane, ML, Handler, EG, Levine, RL, et al. Rasmussen encephalitis: epilepsia partialis continua secondary to chronic encephalitis. Pediatr Neurol 1990; 6: 397401.Google Scholar
4.Andermann, F.Chronic encephalitis and epilepsy. In: Andermann, F, ed. Rasmussen’s Syndrome. Stoneham, MA: Butterworth-Heinemann, Reed Publishing Co, 1991; 141145.Google Scholar
5.Walter, GF, Renella, RR.Epstein-Barr virus in brain and Rasmussen’s encephalitis. Lancet 1989; 1: 279280.Google Scholar
6.Walter, GF, Renella, RR, Hori, A, et al. Nachweis von Epstein-Barr-Viren bei Rasmussen’s encephalitis. Nervenarzt 1989; 60: 168170.Google Scholar
7.Power, C, Poland, SD, Blume, HD, et al. Cytomegalovirus and Rasmussen’s encephalitis. Lancet 1990; 2: 12821284.Google Scholar
8.Gupta, PC, Roy, S, Tandon, PN.Progressive epilepsy due to chronic persistent encephalitis. Report of four cases. J Neurol Sci 1974; 22: 105120.Google Scholar
9.Miyazaki, M, Hashimoto, T, Fujino, K, et al. Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha. Ann Neurol 1991; 29: 9799.Google Scholar
10.Smith, RA.Interferon Treatment of Neurologic Disorders. Marcel Deffer Inc, 1988; 187207.Google Scholar
11.Andermann, F.Chronic encephalitis and epilepsy. In: Andermann, F, ed. Rasmussen’s syndrome. Stoneham, MA: Butterworth-Heinemann, Reed Publishing Co, 1991; 6172.Google Scholar
12.Hwang, PA, Gilday, DL, Ash, JM, et al. Perturbations in cerebralblood flow detected by SPECT scanning with 99Tc-Hm-PAO correlate with EEG abnormalities in children with epilepsy. J Cerebral Blood Flow Metab 1987; 7 (Suppl 1): S573.Google Scholar
13.Rasmussen, T, Villemure, JG.Cerebral hemispherectomy for seizures with hemiplegia. Cleve Clin J Med 1989; 56 (Suppl part 1): 562568.Google Scholar
14.Smith, RA.Interferon Treatment of Neurologic Disorders. Marcel Deffer Inc, 1988; 135156.Google Scholar
15.Ford, RJ, Maizel, AL.Modulators in Cell Growth and Differentiation. New York: Raven Press, 1985; 261281.Google Scholar