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Influence of Nicotinamide on Neurobehavioral Effects of 3-Acetylpyridine

Published online by Cambridge University Press:  18 September 2015

F.B. Jolicoeur ,
C.M. Barbeau ,
G. De Michele  and
A. Barbeau
F.B. Jolicoeur
Affiliation:
Department of Neurobiology. Clinical Research Institute of Montreal
C.M. Barbeau
Affiliation:
Department of Neurobiology. Clinical Research Institute of Montreal
G. De Michele
Affiliation:
Department of Neurobiology. Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Neurobiology. Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montréal, Quebec, Canada H2W 1R7
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Abstract:

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The purpose of the present study was to examine the ability of nicotinamide to prevent the appearance of neurobehavioral symptoms induced by 3-acetyl pyridine (3-AP) in rats. Nicotinamide in doses of 5,50 and 500 mg/kg was injected immediately after administration of 65 mg/kg 3-AP, and neurobehavioral measurements were made at 6, 12, 24, 48 and 72 hours after injections. The effects of 500 mg/kg nicotinamide injected at 3 and 6 hours after 3-AP treatment were also investigated. The results indicate that, starting at 50 mg/kg, nicotinamide can protect animals against most of the neurobehavioral effects of 3-AP. However, the muscular rigidity induced by 3-AP can only be reversed by 500 mg/kg nicotinamide, and the depressing influence of 3-AP on locomotor activity is not blocked by any of the doses of nicotinamide tested. In terms of time course, the protective action of 500 mg/kg is seen when injected 3, but not 6 hours after 3-AP.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 2 , May 1982 , pp. 175 - 178
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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