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Infant with Macrocephaly, Refractory Seizures, and a Leukodystrophy

Published online by Cambridge University Press:  14 August 2023

Kathryn Yang ,
Ryan T. Muir Open the ORCID record for Ryan T. Muir [Opens in a new window] ,
Magda Nowicki ,
Helen Branson  and
Puneet Jain Open the ORCID record for Puneet Jain [Opens in a new window]
Kathryn Yang
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Ryan T. Muir
Affiliation:
Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Magda Nowicki
Affiliation:
Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Helen Branson
Affiliation:
Division of Neuroradiology, Department of Medical Imaging, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Puneet Jain*
Affiliation:
Epilepsy Program, Division of Neurology, Department of Paediatrics, The Hospital for Sick Childrenm University of Toronto, Toronto, ON, Canada
*
Corresponding author: P. Jain; Email: [email protected]
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Abstract

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Keywords

Alexander diseaseGFAPketogenic dietcytokinesfornix
Type
Neuroimaging Highlight
Information
Canadian Journal of Neurological Sciences , First View , pp. 1 - 2
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

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References

Zhang, J, Ban, T, Zhou, L, et al. Epilepsy in children with leukodystrophies. J Neurol. 2020;267: 2612–8.CrossRefGoogle ScholarPubMed
Hamada, S, Kato, T, Kora, K, et al. Ketogenic diet therapy for intractable epilepsy in infantile Alexander disease: a small case series and analyses of astroglial chemokines and proinflammatory cytokines. Epilepsy Res. 2021;170:106519.CrossRefGoogle ScholarPubMed
Olabarria, M, Putilina, M, Riemer, EC, et al. Astrocyte pathology in Alexander disease causes a marked inflammatory environment. Acta Neuropathol. 2015;130:469–86.CrossRefGoogle Scholar
Kora, K, Kato, T, Ide, M, et al. Inflammatory neuropathology of infantile Alexander disease: a case report. Brain Dev. 2020;42:64–8.CrossRefGoogle ScholarPubMed
Thomas, AG, Koumellis, P, Dineen, RA. The fornix in health and disease: an imaging review. Radiographics. 2011;31:1107–21.CrossRefGoogle ScholarPubMed