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Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?

Published online by Cambridge University Press:  02 December 2014

D. Salat-Foix ,
K. Tran ,
R. Ranawaya ,
J. Meddings  and
O. Suchowersky
D. Salat-Foix*
Affiliation:
Movement Disorders Program, Department of Clinical Neurosciences, University of Calgary, Calgary
K. Tran
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, University of Calgary, Calgary
R. Ranawaya
Affiliation:
Movement Disorders Program, Department of Clinical Neurosciences, University of Calgary, Calgary
J. Meddings
Affiliation:
Division of Gastroenterology, Department of Internal Medicine, University of Calgary, Calgary
O. Suchowersky
Affiliation:
Department of Medicine (Neurology) and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
*
Movement Disorders Program. Department of Clinical Neurosciences, Area 3, UCMC, 3350 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.
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Abstract

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Gastrointestinal involvement is a frequent and early event in the course of Parkinson Disease (PD), and may have a prominent role in the early pathophysiology of the disease. On the other hand, derangement in intestinal permeability could also result from the involvement of the gastrointestinal tract over the course of the disease.

Patients and methods:

The intestinal permeability of 12 non-selected PD patients was studied using a validated, non-invasive test; these results were compared to predefined age-adjusted reference values.

Results:

4/12 PD patients had abnormal gastrointestinal permeability; two had both an abnormal lactulose/mannitol ratio and an abnormal sucrose concentration, and two an isolated abnormal result. An increased lactulose/mannitol ratio is consistent with defect of either the enterocytes or the tight junctions between them.

Conclusion:

Intestinal permeability is increased in a significant proportion of unselected PD patients with minimal gastrointestinal symptoms. The significance of this finding needs to be further evaluated.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 2 , March 2012 , pp. 185 - 188
Copyright
Copyright © The Canadian Journal of Neurological 2012

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