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Increased Basal Ganglia Iron in Striatonigral Degeneration: In Vivo Estimation with Magnetic Resonance

Published online by Cambridge University Press:  18 September 2015

W.R. Wayne Martin*
Affiliation:
Division of Neurology, University of Alberta, Edmonton Department of Biomedical Engineering, University of Alberta, Edmonton
Ted E. Roberts
Affiliation:
Division of Neurology, University of Alberta, Edmonton
Frank Q. Ye
Affiliation:
Department of Biomedical Engineering, University of Alberta, Edmonton
Peter S. Allen
Affiliation:
Department of Biomedical Engineering, University of Alberta, Edmonton
*
Movement Disorder Clinic, Glenrose Rehabilitation Hospital, 10230 - 111 Avenue, Edmonton, Alberta, Canada T5G 0B7
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Abstract:

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Background:

As many as 20% of individuals with the clinical diagnosis of Parkinson's disease (PD) do not have the characteristic neuropathologic features of PD at post mortem. The striatonigral degeneration (SND) subtype of multiple system atrophy is one of the categories of pathology which may be incorrectly diagnosed as PD on the basis of clinical presentation. SND may be associated with increased iron deposition in the putamen which can be detected with magnetic resonance imaging.

Methods:

We have estimated regional brain iron content in a patient with probable SND, using a novel imaging method developed in our laboratory, and have compared the results in this patient to those which we have previously reported in patients with PD and in age-matched controls.

Results:

We observed that putamenal iron content was increased in our SND patient, beyond the 95% confidence limit for inclusion in the PD group, even when considering clinical severity. In contrast, pallidal and thalamic iron were within the PD range.

Conclusions:

The demonstration of increased putamenal iron content may be a useful adjunctive investigative procedure in patients with suspected SND.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

References

REFERENCES

1.Hughes, AJ, Daniel, SE, Kilford, L, Lees, AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 1992; 55: 181184.CrossRefGoogle ScholarPubMed
2.Stern, MB, Braffman, BH, Skolnick, BE, Hurtig, HI, Grossman, RI. Magnetic resonance imaging in Parkinson’s disease and parkinsonian syndromes. Neurology 1989; 39: 15241526.CrossRefGoogle ScholarPubMed
3.Pasatakia, B, Polinsky, R, De Chiro, G, et al. Multiple system atrophy (Shy-Drager syndrome): MR imaging. Radiology 1990; 174: 609696.Google Scholar
4.Drayer, BP, Olanow, W, Burger, P, et al. Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron. Radiology 1986; 159:493498.CrossRefGoogle Scholar
5.Gorell, JM, Ordidge, RJ, Brown, GG , et al. Increased iron-related MRI contrast in the substantia nigra in Parkinson’s disease. Neurology 1995; 45: 11381143.CrossRefGoogle ScholarPubMed
6.Ye, FQ, Allen, PS, Martin, WRW. Basal ganglia iron content in Parkinson’s disease measured with magnetic resonance. Mov Dis 1996; 11:243-–249.CrossRefGoogle ScholarPubMed
7.Folstein, MF, Folstein, SE, Mchugh, PR. “Mini-mental state”: a practical method for grading the mental state of patients for the clinician. J Psychiatr Res 1975; 12: 189198.CrossRefGoogle ScholarPubMed
8.Ye, FQ, Allen, PS. Ferritin as a susceptibility agent. In: Proceedings of the 12th Annual Meeting of Society of Magnetic Resonance in Medicine. Berkeley: Society of Magnetic Resonance, 1993: 800.Google Scholar
9.Ye, FQ, Allen, PS. Relaxation enhancement of the transverse magnetization of water protons in paramagnetic suspensions of red blood cells. Magn Reson Med 1995; 34: 713720.CrossRefGoogle ScholarPubMed
10.Ye, FQ, Martin, WRW, Allen, PS. Estimation of brain iron in vivo by means of the interecho time dependence of image contrast. Magn Reson Med 1996; 36: 153158.CrossRefGoogle ScholarPubMed
11.Ye, FQ, Martin, WRW, Allen, PS. Estimation of the iron concentration in excised grey matter by means of proton relaxation measurements. Magn Reson Med 1996; 35: 285289.CrossRefGoogle ScholarPubMed
12.Fahn, S, Elton, RL. Unified Parkinson’s disease rating scale. In: Fahn, Set al., eds. Recent Developments in Parkinson’s Disease, Vol 2. Florham Park: Macmillan, 1987: 153163.Google Scholar
13.Schwab, RS, England, AC. Projection technique for evaluating surgery in Parkinson’s disease. In: Gillingham, FJ, Donaldson, IML, eds. Third Symposium on Parkinson’s Disease. Edinburgh: Livingstone, 1969: 152157.Google Scholar
14.Wenning, GK, Ben Shlomo, Y, Magalhaes, M, Daniel, SE, Quinn, NP. Clinical features and natural history of multiple system atrophy. An analysis of 100 cases. Brain 1994; 117: 835845.CrossRefGoogle ScholarPubMed
15.O’Brien, C, Sung, JH, Mcgeachie, RE, Lee, MC. Striatonigral degeneration : clinical, MRI and pathological correlation. Neurology 1990;40:710711.CrossRefGoogle Scholar
16.Lang, AE, Curran, T, Provias, J, Bergeron, C. Striatonigral degeneration : iron deposition in putamen correlates with the slit-like void signal of magnetic resonance imaging. Can J Neurol Sci 1994; 21:311318.CrossRefGoogle ScholarPubMed
17.Schwarz, J, Weis, S, Kraft, E, et al. Signal changes on MRI and increases in reactive microgliosis, astrogliosis, and iron in the putamen of two patients with multiple system atrophy. J Neurol Neurosurg Psychiatry 1996; 60: 98101.CrossRefGoogle ScholarPubMed
18.Eidelberg, D, Takikawa, S, Moeller, JR, et al. Striatal hypometabolism distinguishes striatonigral degeneration from Parkinson’s disease. Ann Neurol 1993; 33: 518527.CrossRefGoogle ScholarPubMed
19.Kato, S, Meshitsuka, S, Ohama, E, et al. Increased iron content in the putamen of patients with striatonigral degeneration. Acta Neuropathologica 1992; 84: 328330.CrossRefGoogle ScholarPubMed